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undergraduate thesis
Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:691493
Iveša, Marko
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Iveša, M. (2022). Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:691493

Iveša, Marko. "Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:691493

Iveša, Marko. "Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:691493

Iveša, M. (2022). 'Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:159:691493

Iveša M. Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:691493

M. Iveša, "Primjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:691493

Metadata
TitlePrimjena rekombinantnih mikroorganizama u proizvodnji biofarmaceutika
Title (english)Application of recombinant microorganisms in biopharmaceutical production
AuthorMarko Iveša
MentorBlaženka Kos (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology)
Zagreb
Defense date and country2022-06-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Od staničnih linija jajnika kineskog hrčka (CHO) i eukariotskih mikroorganizama do sojeva aktinomiceta i drugih bakterija, u proizvodnji biofarmaceutika uglavnom se koriste rekombinantni organizmi dobiveni metodama genetičkog inženjerstva nakon provedenog sekvencioniranja genoma i provedenih analiza primjenom bioinformatičkih alata. Prije razvoja suvremenih tehnologija, evolucija je bila jedini način da se poboljšaju svojstva radnog mikroorganizma. Broj modela, metoda i instrumenata dostupnih za provođenje genetičkih izmjena domaćina sve je veći te su i mogućnosti dobivanja rekombinantnih radnih mikroorganizama s poželjnim svojstvima poboljšane. U ovom je radu dan pregled primjene metoda genetičkog inženjerstva u kreiranju rekombinantnih organizama namijenjenih biotehnološkoj proizvodnji farmaceutika. Opisani su modelni organizmi, potencijalni radni organizmi koji mogu poslužiti kao platforma zbog povoljnih metaboličkih svojstava ili fizioloških značajki i rekombinantne stanice mikroorganizama i stanične linije biljaka, sisavaca i kukaca. Posebno je obrađena važnost posttranslacijskih modifikacija u proizvodnji biofarmaceutika te proizvodne strategije koje omogućuju primjenu najsusvremenijih metoda na radne organizme time omogučavajući ekonomičnost proizvodnje novih lijekova.
Abstract (english)
From Chinese hamster ovary (CHO) cell lines and eukaryotic microorganisms to actinomycetes and other bacterial strains, the production of biopharmaceuticals mainly uses recombinant organisms obtained by genetic engineering methods after genome sequencing and analysis using bioinformatics tools. Prior to the development of modern technologies, evolution was the only way to improve the properties of the working microorganism. The number of models, methods and instruments available for the genetic modification of hosts is increasing and the possibilities of obtaining recombinant working microorganisms with desirable properties have been improved. Model organisms, potential working organisms that can serve as a platform due to favorable metabolic properties or physiological characteristics, and recombinant microorganisms and plant, mammalian and insect cell lines are described. The importance of post-translational modifications in the production of biopharmaceuticals and production strategies that enable the application of state-of-the-art methods to working organisms, thus enabling the cost-effectiveness of the production of new drugs, is especially discussed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:691493
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2022-10-05 13:41:36