prikaz prve stranice dokumenta Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima
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undergraduate thesis
Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. urn:nbn:hr:159:798976
Čače, Alan
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Čače, A. (2014). Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:798976

Čače, Alan. "Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:798976

Čače, Alan. "Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2014. https://urn.nsk.hr/urn:nbn:hr:159:798976

Čače, A. (2014). 'Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:798976

Čače A. Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2014 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:798976

A. Čače, "Ferocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:159:798976

Metadata
TitleFerocen 1,1diamin kao začetnik elemenata sekundarne strukture u izvedenim peptidima
Title (english)Ferrocene 1,1 diamine as inducer of secondary structure elements in the derived peptides
AuthorAlan Čače
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2014-09-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
U ovom radu opisani su sinteza i konformacijska svojstva ferocenskih peptida III [Ac-Ala-Fn-Ala-Y; Y = Boc (5), Y=Ac (6)] koji su izvedeni kondenzacijom ferocen-1,1'-diamina (Fcda) i L-alanina. Da bi se ispitala uloga Fcda i pri tvorbi IHB kao i utjecaj zaštitnih skupina (Ac i Boc) na konformacijski prostor koji peptidi 5 i 6 poprimaju u otopini, provedena je spektroskopska analiza (IR-, 1H NMR- i CD-spektroskopija) i DFT-modeliranje, dok je za peptid 5 određena i kristalografska struktura. Pokazalo se da su konjugati III stabilizirani interlančanim vodikovim vezama, dok zamjena voluminozne Boc-zaštitne skupine s Ac-skupinom nije dovela do većih konformacisjkih promjena.
Abstract (english)
This study has explored the synthesis and structural characteristics of ferrocene peptides III [Ac-Ala-Fn-Ala-Y; Y = Boc (5), Y=Ac (6)], derived by condensation of ferrocene-1,1'-diamine (Fcda) and L-alanine. In order to explore influence of diamine, as well as effects of protecting groups (Ac, Boc) on the conformational space of the derived ferrocene diamines 5 and 6, the detailed conformational analysis (IR, 1H NMR and CD spectroscopy, DFT calculations) was performed. Crystallographic structure of peptide 5 was determined. It was demonstrated that conjugates III were stabilized through interchain hydrogen bonding, while the replacement of the bulky Boc group with an Ac group did not cause major conformational changes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:798976
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-27 09:33:47