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master's thesis
Analiza matematičkog modela regulacije metabolizma glukoze
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:793012
Gošev, Dora
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Gošev, D. (2022). Analiza matematičkog modela regulacije metabolizma glukoze (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:793012

Gošev, Dora. "Analiza matematičkog modela regulacije metabolizma glukoze." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:793012

Gošev, Dora. "Analiza matematičkog modela regulacije metabolizma glukoze." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:793012

Gošev, D. (2022). 'Analiza matematičkog modela regulacije metabolizma glukoze', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 07 October 2024, https://urn.nsk.hr/urn:nbn:hr:159:793012

Gošev D. Analiza matematičkog modela regulacije metabolizma glukoze [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 October 07] Available at: https://urn.nsk.hr/urn:nbn:hr:159:793012

D. Gošev, "Analiza matematičkog modela regulacije metabolizma glukoze", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:793012

Metadata
TitleAnaliza matematičkog modela regulacije metabolizma glukoze
Title (english)Analysis of a mathematical model of glucose metabolism regulation
AuthorDora Gošev
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2022-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
U ovom radu provedena je računalna analiza modela metabolizma glukoze primjenom programskog paketa CellDesigner. Provedene su simulacije modela s različitim početnim koncentracijama glukoze i inzulina, koje su ovisile o konzumiranom obroku. U tu svrhu osmišljena su 3 jelovnika: jelovnik za dijabetičare, jelovnik s malim udjelom ugljikohidrata i jelovnik za opću populaciju. Rezultati pokazuju najveće skokove, kao i padove, kod obroka koji su bogati glukozom, dok su obroci iz jelovnika za dijabetičare imali postupan pad do bazalne vrijednosti glukoze. Također je provedena analiza lokalne parametarske osjetljivosti kako bi se identificirali najosjetljiviji metaboliti modela. Rezultati ističu važnost inzulina u regulaciji glukoze i održavanju vrijednosti glukoze u krvi unutar referentnih vrijednosti. Korišteni model uspješno simulira metabolizam glukoze za odabrani raspon početnih vrijednosti.
Abstract (english)
Computer analysis of the glucose metabolism model was performed using the CellDesigner software package. Simulations of the models were conducted, each of them having different glucose and insulin values, depending on a consumed meal. For that purpose, three different menus were made: a menu for diabetics, a menu containing low amounts of carbohydrates and a menu for general population. Results show the biggest jumps, as well as drops, for meals that are high in glucose, while meals made for diabetics show a gradual decline in basal glucose values. Analysis of local parameter sensibility was also conducted to identify the most sensitive metabolite. The results of simulations indicate the importance of hormone insulin in glucose regulation and maintaining blood glucose values in a healthy range. Model that was used successfully simulates glucose metabolism for selected range of initial values.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:793012
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2023-02-22 08:44:04