prikaz prve stranice dokumenta Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina
  Download
PDF 1.24 MB
master's thesis
Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:648454
Cikron, Miriam
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Food Engineering
Laboratory for Fermentation and Yeast Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Cikron, M. (2022). Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:648454

Cikron, Miriam. "Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:648454

Cikron, Miriam. "Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:648454

Cikron, M. (2022). 'Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:648454

Cikron M. Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:159:648454

M. Cikron, "Antimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:648454

Metadata
TitleAntimikrobna i antioksidacijska aktivnost ferocenskih peptida dobiveni iz ferocen-1,1'-diamina
Title (english)Antimicrobial and antioxidant activity of ferrocene peptides derived from ferrocene 1,1 diamine
AuthorMiriam Cikron
MentorJasna Mrvčić (mentor)
Committee memberMonika Kovačević (predsjednik povjerenstva)
Committee memberLidija Barišić (član povjerenstva)
Committee memberDamir Stanzer (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Food Engineering)
(Laboratory for Fermentation and Yeast Technology)
Zagreb
Defense date and country2022-07-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
U literaturi je prisutno sve više podataka o antimikrobnoj rezistenciji, posebice o rezistenciji na više lijekova koji se koriste u terapiji protiv gram-pozitivnih i gram-negativnih bakterija. Budući da su multirezistentni bakterijski sojevi sve rašireniji i brojniji, u cilju zaštite zdravlja važno je osigurati nove, učinkovite antimikrobne agense. Shodno tome, istražuju se potencijalni antimikrobni peptidi s ugrađenom ferocenskom jedinicom. U ovom je radu za osamnaest sintetiziranih ferocenskih peptida ispitana potencijalna antimikrobna i antioksidativna aktivnost. Antimikrobna aktivnost određena je disk difuzijskom metodom, metodom razrjeđivanja bujona i metodom brojanja kolonija, a u svrhu istraživanja antioksidacijske aktivnosti korištene su FRAP i DPPH metode. Biokonjugatima Ac-L-Ala-D-Pro-NH-Fn-NH-D-Pro-Boc (4) i Ac-D-Ala-D-Pro-NH-Fn-NH-L-Pro-Boc (5) iz skupine ferocenskih peptida IIIc, koji su pokazali antimikrobno djelovanje disk difuzijskom metodom prema test mikroorganizmima: S. aureus, E. faecium, P. aeruginosa i E. coli, određena je minimalna inhibitorna koncentracija prema navedenim bakterijskim vrstama i iznosi > 2 mM.
Abstract (english)
There is increasing evidence in the literature of antimicrobial resistance, often resistance to multiple drugs used in the therapy against gram-positive and gram-negative bacteria. As multidrug-resistant bacterial strains become more widespread and numerous, it is important to provide new, effective antimicrobial agents tp protect health. Potential antimicrobial agents are ferrocene peptides, and their biological evaluation is investigated in this work. Biological evaluation of eighteen synthesized ferrocene peptides was performed by determining their potential antimicrobial and antioxidant activities. The antimicrobial activity was studied by the disk diffusion method, broth dilution method and colony counting method, while the antioxidant activity was determined by the FRAP and DPPH. The bioconjugates Ac-L-Ala-D-Pro-NH-Fn-NH-D-Pro-Boc (4) and Ac-D-Ala-D-Pro-NH-Fn-NH-L-Pro-Boc (5) from the group of ferrocene peptides IIIc, showed antimicrobial activity by the disk diffusion method according to test microorganisms: S. aureus, E. faecium, P. aeruginosa and E. coli. The minimum inhibitory concentration was determined according to these bacterial species and is > 2 mM.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:648454
Study programmeTitle: Food Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka prehrambenog inženjerstva (magistar/magistra inženjer/inženjerka prehrambenog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2023-06-02 10:54:11