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master's thesis
Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:722629
Biličić, Lea
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biology and Microbial Genetics

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Biličić, L. (2022). Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:722629

Biličić, Lea. "Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:722629

Biličić, Lea. "Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:722629

Biličić, L. (2022). 'Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 May 2024, https://urn.nsk.hr/urn:nbn:hr:159:722629

Biličić L. Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 May 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:722629

L. Biličić, "Učinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:722629

Metadata
TitleUčinci prenatalne izloženosti α-cipermetrinu na endokrinu disrupciju reprodukcije i razvoja muških potomaka pokusnih štakora
Title (english)Effects of prenatal exposure to α-cypermethrin on endocrine disruption of reproduction and development of male laboratory rat offspring
AuthorLea Biličić
MentorKsenija Durgo (mentor)
Committee memberVišnja Gaurina-Srček (predsjednik povjerenstva)
Committee memberAnja Katić (član povjerenstva)
Committee memberJasna Mrvčić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biology and Microbial Genetics)
Zagreb
Defense date and country2022-07-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Brojni pesticidi djeluju kao hormonski otrovi, koji ovisno o razdoblju izloženosti mogu pridonijeti razvoju reproduktivnih poremećaja kod muškaraca i žena. U ovom radu ispitan je utjecaj potencijalnog hormonskog otrova, piretroida α-cipermetrina, na endokrinu disrupciju reprodukcije i razvoja prenatalno izloženih muških potomaka pokusnih štakora. S ciljem utvrđivanja učinaka prenatalne izloženosti α-cipermetrinu na razvoj muških mladunaca F1 generacije promatrani su: anogenitalni razmak, postojanje areola/bradavica i vanjski znakovi spolnog sazrijevanja. Izmjerene su i tjelesne mase muških mladunaca u pubertetu te mase njihovih testisa. Učinci prenatalne izloženosti α-cipermetrinu na reprodukciju muških mladunaca F1 generacije ispitani su praćenjem parametara endokrine disrupcije prema odgovarajućim OECD protokolima. Također su procijenjene razine testosterona u serumu muških fetusa i razine testosterona i progesterona u serumu muških mladunaca u pubertetu imunokemijskom metodom ELISA.
Abstract (english)
A large number of pesticides act as endocrine disruptors. They could contribute to the development of reproductive disorders in men and women, depending on the period of exposure. In this research we investigated the effect of potential endocrine disruptor, pyrethroid α-cypermethrin, on endocrine disruption of reproduction and the development of prenatally exposed male laboratory rat offspring. In order to determine the effects of prenatal exposure to α-cypermethrin on the development of F1 male offspring anogenital distance, areola/nipple retention and external signs of sexual maturation were monitored. The body mass of pubertal male offspring and mass of their testes were measured. Effects of prenatal exposure to α-cypermethrin on the reproduction of F1 male offspring were investigated by monitoring parameters of endocrine disruption according to the appropriate OECD protocols. The levels of testosterone in foetal serum and testosterone and progesterone in serum of pubertal male offspring were measured using immunochemical method ELISA.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:722629
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2023-10-06 09:40:47