prikaz prve stranice dokumenta Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina
  Download
PDF 859.94 KB
undergraduate thesis
Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:134599
Jelaska, Laura
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Jelaska, L. (2023). Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:134599

Jelaska, Laura. "Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:134599

Jelaska, Laura. "Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:134599

Jelaska, L. (2023). 'Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 11 October 2024, https://urn.nsk.hr/urn:nbn:hr:159:134599

Jelaska L. Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 October 11] Available at: https://urn.nsk.hr/urn:nbn:hr:159:134599

L. Jelaska, "Konformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:134599

Metadata
TitleKonformacijska analiza peptidomimetika izvedenog iz alanina, fenilalanina i ferocen-1,1'-diamina
Title (english)Conformational analysis of peptidomimetic derived from alanine, phenylalanine and ferrocene-1,1'-diamine
AuthorLaura Jelaska
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2023-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Ferocen je sendvič spoj koji se sastoji od dva paralelna ciklopentadienilna prstena između kojih se nalazi atom željeza. Zbog svojih povoljnih svojstava koristi se kao kalup pri sintezi peptidomimetika. Peptidomimetici su spojevi koji imaju sposobnost imitiranja sekundarne strukture proteina. Upotreba peptidomimetika je od iznimne važnosti, budući da se peptidi i proteini, zbog svojih brojnih nepovoljnih svojstava, ne mogu koristiti u kliničke te terapeutske svrhe. Jedan od načina pripreme peptidomimetika je „umetanje“ ferocenskog kalupa u peptidni lanac. Ciklopentadienilni prstenovi ferocena nalaze na udaljenosti od 3,3 Å, što omogućuje stvaranje intramolekulskih vodikovih veza između dva peptidna lanca, vezana na ferocen. Cilj ovog Završnog rada bio je, iz ferocen-1,1'- diamina i aminokiselina L-alanin i L-fenilalanin, sintetizirati peptid, Ac-L-Ala-NH-Fn-NH-L-Phe-Boc (1). Upotrebom infracrvene spektrometrije te nuklearne magnetske rezonancije učinjena je spektrometrijska analiza peptida 1, kako bi se dobile informacije o prirodi nastalih vodikovih veza. Dokazano je da u pripravljenom peptidu dolazi do tvorbe dviju interlančanih vodikovih veza koje induciraju tvorbu γ-okreta.
Abstract (english)
Ferrocene is a sandwich compound consisting of two parallel cyclopentadienyl rings with an iron atom in the middle. Due to its favorable properties, it is used as a form in the synthesis of peptidomimetics. Peptidomimetics are compounds that have the ability to mimic the secondary structure of proteins. The use of peptidomimetics is extremely important, because peptides and proteins cannot be used for clinical and therapeutic purposes due to their many unfavorable properties. One method of preparing peptidomimetics is to "insert" a ferrocene template into a peptide chain. The cyclopentadienyl rings of ferrocene are located at a distance of 3,3 Å which allows the formation of intramolecular hydrogen bonds between two peptide chains attached to ferrocene. The aim of this work was to synthesize the peptide, Ac-L-Al-NH-L-Phe-Boc (1) from ferrocene1,1-diamine and the amino acids L-alanine and L-phenylalanine. Infrared spectrometry and nuclear magnetic resonance were used to perform spectrometric analysis of peptide 1 to obtain information on the nature of the hydrogen bonds formed. Two hydrogen bonds are formed between the chains, which induce the formation of γ-turn in the prepared peptide 1.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:134599
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-04-16 11:20:38