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undergraduate thesis
Terapija tumora T-stanicama s kimernim antigenskim receptorima
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:989705
Grahek, Petra
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Grahek, P. (2023). Terapija tumora T-stanicama s kimernim antigenskim receptorima (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:989705

Grahek, Petra. "Terapija tumora T-stanicama s kimernim antigenskim receptorima." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:989705

Grahek, Petra. "Terapija tumora T-stanicama s kimernim antigenskim receptorima." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:989705

Grahek, P. (2023). 'Terapija tumora T-stanicama s kimernim antigenskim receptorima', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 October 2024, https://urn.nsk.hr/urn:nbn:hr:159:989705

Grahek P. Terapija tumora T-stanicama s kimernim antigenskim receptorima [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 October 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:989705

P. Grahek, "Terapija tumora T-stanicama s kimernim antigenskim receptorima", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:989705

Metadata
TitleTerapija tumora T-stanicama s kimernim antigenskim receptorima
Title (english)Tumor therapy with T-cells with chimeric antigen receptors
AuthorPetra Grahek
MentorBlaženka Kos (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Antibiotic, Enzyme, Probiotic and Starter Cultures Technology)
Zagreb
Defense date and country2023-06-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Žive stanice su najnovija generacija bioloških lijekova tzv. biofarmaceutika, kojima pripadaju T-stanice s kimernim antigenskim receptorima (CAR – engl. chimeric antigen receptor) namijenjene terapiji tumora. CAR T-stanice prepoznaju specifične antigene na površini stanica tumora i uništavaju ih. Prva takva stanična imunoterapija je odobrena 2017. godine, a uključuje također terapiju tumor-infiltrirajućim limfocitima (TIL) i prirodnim stanicama ubojicama (NK, engl. natural killer). Cilj ovog rada je bio opisati mehanizam terapijskog djelovanja CAR T-stanica, njihovu terapijsku primjenu, značaj, prednosti, nedostatke i daljnje mogućnosti razvoja ovog terapijskog pristupa. U svrhu razvoja CAR Tstanica kao lijekova, izolirani limfociti pacijenta se genetički modificiraju ex vivo radi dobivanja rekombinantnih CAR T-stanica koje će imati terapijski učinak. Terapija CAR T-stanicama smatra se revolucionarnom, te se očekuje primjena ovog terapijskog pristupa i za druge karcinome, pa čak i za zarazne i autoimune bolesti.
Abstract (english)
Living cells are the latest generation of biopharmaceuticals, which include T-cells with chimeric antigen receptors (CAR – English chimeric antigen receptor) intended for tumor therapy. CAR T-cells recognize specific antigens on the surface of tumor cells and destroy them. The first cellular immunotherapy was approved in 2017, and it also includes therapy with tumor-infiltrating lymphocytes (TIL) and natural killer cells (NK). The aim of this work was to describe the mechanism of the therapeutic effect of CAR T-cells, their therapeutic application, significance, advantages, disadvantages and further possibilities for the development of this therapeutic approach. In order to develop CAR Tcells as drugs, the patient's isolated lymphocytes are genetically modified ex vivo to obtain recombinant CAR T-cells that will have a therapeutic effect. CAR T-cell therapy is considered revolutionary, and the application of this therapeutic approach is expected for other cancers, and even for infectious and autoimmune diseases.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:989705
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-04-19 11:59:56