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undergraduate thesis
Modeli za ispitivanje dermalne toksičnosti
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. urn:nbn:hr:159:618830
Račić, Nikolina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Toxicology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Račić, N. (2022). Modeli za ispitivanje dermalne toksičnosti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:618830

Račić, Nikolina. "Modeli za ispitivanje dermalne toksičnosti." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:618830

Račić, Nikolina. "Modeli za ispitivanje dermalne toksičnosti." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2022. https://urn.nsk.hr/urn:nbn:hr:159:618830

Račić, N. (2022). 'Modeli za ispitivanje dermalne toksičnosti', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 26 June 2024, https://urn.nsk.hr/urn:nbn:hr:159:618830

Račić N. Modeli za ispitivanje dermalne toksičnosti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2022 [cited 2024 June 26] Available at: https://urn.nsk.hr/urn:nbn:hr:159:618830

N. Račić, "Modeli za ispitivanje dermalne toksičnosti", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:159:618830

Metadata
TitleModeli za ispitivanje dermalne toksičnosti
Title (english)Models for skin toxicity testing
AuthorNikolina Račić
MentorMarina Miletić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Toxicology)
Zagreb
Defense date and country2022-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Bolničke infekcije značajan su zdravstveni problem koji povećava morbiditet i mortalitet bolesnika te se u što većoj mjeri nastoji reducirati prisutnost patogenih mikroorganizama u bolničkom okruženju. Sprječavanje rasta bakterija i gljivica pogotovo na tekstilu namijenjenom za bolnice postao je jedan od novih izazova za čovjeka. Tekstil dolazi u izravni kontakt s kožom pa je važno ispitati potencijalni toksični utjecaj antimikrobno obrađenog tekstila na kožu. Korištena je HaCaT stanična linija humanih keratinocita te je primijenjena MTT metoda 72 sata nakon tretmana. Rezultati su pokazali kako sva ispitana razrjeđenja kao i ishodna otopina dobivena ekstrakcijom antimikrobno obrađene pamuk/poliester tkanine smanjuju proliferaciju i vijabilnost HaCaT stanica. Također, primijećeno je kako tekstil koji je više puta opran uzrokuje manje smanjenje vijabilnosti i proliferacije stanica, vjerojatno zbog ispiranja antimikrobnog agensa kojim je tekstilija tretirana.
Abstract (english)
Hospital infections are a significant health problem that increases patient’s morbidity and mortality, and efforts are being made to reduce the presence of pathogenic microorganisms in the hospital environment as much as possible. Preventing the growth of bacteria and fungi, especially on textiles intended for hospitals, has become one of the new challenges. Textile comes into direct contact with the skin, so it is important to examine the potential cytotoxic impact of antimicrobial treated textiles on the skin. The HaCaT cell line of human keratinocytes was used and the MTT method was applied 72 hours after the treatment. The results showed that all tested dilutions as well as the initial solution obtained by extraction of antimicrobial treated cotton/polyester fabric reduce the proliferation and viability of HaCaT cells. Also, it was observed that textiles that have been washed several times cause a smaller decrease in cell viability and proliferation, probably due to the washing off the antimicrobial agent with which the textile was treated.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:618830
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-04-23 11:35:40