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undergraduate thesis
Priprava merkaptopurinskih biokonjugata ferocena
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:712967
Komarec, Klara
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Komarec, K. (2023). Priprava merkaptopurinskih biokonjugata ferocena (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:712967

Komarec, Klara. "Priprava merkaptopurinskih biokonjugata ferocena." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:712967

Komarec, Klara. "Priprava merkaptopurinskih biokonjugata ferocena." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:712967

Komarec, K. (2023). 'Priprava merkaptopurinskih biokonjugata ferocena', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 17 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:712967

Komarec K. Priprava merkaptopurinskih biokonjugata ferocena [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 August 17] Available at: https://urn.nsk.hr/urn:nbn:hr:159:712967

K. Komarec, "Priprava merkaptopurinskih biokonjugata ferocena", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:712967

Metadata
TitlePriprava merkaptopurinskih biokonjugata ferocena
Title (english)Preparation of ferrocene mercaptopurine bioconjugates
AuthorKlara Komarec
MentorJasmina Lapić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2023-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Organometalni derivati nukleobaza (OrDeN-i) nova su generacija konjugata u kojima su povezani metaloceni s temeljnim strukturnim elementima nasljeđivanja. Reakcijom između ferocenoil klorida i purinskih nukleobaza pripravljeno je niz konjugata s karbonilnom poveznicom između heterocikličkog i organometalnog djela u kojem je omjer produkta (N7/N9-ferocenoil izomera) reguliran prostornim svojstvima supstituenta na C6 položaju. U okviru ovog završnog rada pripravljeni su merkaptopurinski biokonjugati ferocena. Aciliranje se provodi s ferocenoil kloridom, u acetonitrilu uz trietilamin kao deprotonirajući agens pri čemu u reakciji s merkaptopurinom nastaje uz monoderivat N7 i bisderivat N9/C6, dok je reakcija s 6-metilmerkaptopurinom regiospecifična reakcija pri čemu nastaje samo N9 produkt. Strukture svih sintetiziranih spojeva karakterizirane su spektrometrijskim tehnikama: NMR i IR spektroskopijom za točnu identifikaciju svakog izomera.
Abstract (english)
Organometallic derivatives of nucleobases (OrDeNs) are a new generation of conjugates in which metallocenes are connected to the basic structural elements of inheritance. The reaction between ferrocenoyl chloride and purine nucleobases prepared a series of conjugates with a carbonyl link between a heterocyclic and an organometallic part, in which the product ratio (N7/N9 -ferrocenoyl isomer) is regulated by the spatial properties of the substituent at the C6 position. As part of this final work, mercaptopurine bioconjugates of ferrocene were prepared. Acylation is carried out with ferrocenoyl chloride, in acetonitrile with triethylamine as a deprotonating agent, whereby in the reaction with mercaptopurine, the monoderivative N7 isomer and the bis derivative N9/C6 are formed, while the reaction with 6-methylmercaptopurine is a regiospecific reaction in which only the N9 product is formed. The structures of all synthesized compounds were characterized by spectrometric techniques: NMR and IR spectroscopy for accurate identification of each isomer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:712967
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-04-29 08:56:28