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master's thesis
Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:514733
Juričić, Josipa
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Juričić, J. (2023). Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:514733

Juričić, Josipa. "Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:514733

Juričić, Josipa. "Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:514733

Juričić, J. (2023). 'Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:514733

Juričić J. Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 September 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:514733

J. Juričić, "Određivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:514733

Metadata
TitleOdređivanje statusa vitamina D analizom matematičkog modela metabolizma vitamina D
Title (english)Determination of vitamin D status by analysis of the mathematical model of vitamin D metabolism
AuthorJosipa Juričić
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2023-06-02, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
U ovom radu provedena je analiza modela metabolizma vitamina D korištenjem računalnog programa CellDesigner pri čemu je određivan status vitamina D. Simulacije modela provedene su koristeći različite početne vrijednosti vitamina D iz hrane koje su dobivene iz jelovnika izrađenih u okviru ovog rada – jelovnik mediteranske prehrane, jelovnik s hranom bogatom vitaminom D, jelovnik s obogaćenom hranom i plan suplementacije. Model uspješno simulira promjenu koncentracije vitamina D i njegovih metabolita. Rezultati pokazuju da suplementacija ima najbolju učinkovitost u liječenju nedostatka vitamina D. Analizom lokalne parametarske osjetljivosti uočeno je da su parametri brzine stvaranja te brzine razgradnje 25-hidroksivitamina D (25(OH)D₃) najosjetljiviji parametri, a primijećeno je i da koncentracija 1,25-dihidroksivitamina D (1,25(OH)₂D₃) nije u potpunosti ovisna o unosu vitamina D prehranom.
Abstract (english)
Analysis of vitamin D metabolism model was performed using the CellDesigner software which was used to determine the vitamin D status. Simulations of the constructed model were conducted using different initial values of dietary vitamin D, obtained from different menus created for the purposes of thesis – Mediterranean diet menu, vitamin D-rich foods menu fortified foods menu and the supplementation plan. Model successfully simulates metabolism of vitamin D and its metabolites. The results show that dietary supplementation is the most effective in the treatment of vitamin D deficiency. Based on the analysis of local parameter sensitivity, it was concluded that the rate of formation and the rate of degradation of 25-hydroxyvitamin D (25(OH)D₃) were estimated to be the most sensitive parameters. It was also observed that the concentration of 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) was not completely dependent on dietary intake of vitamin D.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:514733
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-05-15 12:10:38