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master's thesis
Analiza modela metabolizma kolesterola
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:576332
Sinković, Anđela
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Sinković, A. (2023). Analiza modela metabolizma kolesterola (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:576332

Sinković, Anđela. "Analiza modela metabolizma kolesterola." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:576332

Sinković, Anđela. "Analiza modela metabolizma kolesterola." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:576332

Sinković, A. (2023). 'Analiza modela metabolizma kolesterola', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:576332

Sinković A. Analiza modela metabolizma kolesterola [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 September 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:576332

A. Sinković, "Analiza modela metabolizma kolesterola", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:576332

Metadata
TitleAnaliza modela metabolizma kolesterola
Title (english)Analysis of cholesterol metabolism model
AuthorAnđela Sinković
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2023-03-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
U ovom radu provedena je analiza modela metabolizma kolesterola u računalnom programu CellDesigner. Simulacije modela provedene su koristeći različite početne vrijednosti kolesterola iz hrane koje su dobivene iz jelovnika izrađenih u okviru ovog rada – jelovnik za vegetarijansku prehranu, uravnoteženu prehranu i ketogenu prehranu. Model uspješno simulira promjenu koncentracije kolesterola i njegovih metabolita. Rezultati ukazuju na utjecaj mase kolesterola iz hrane na masu crijevnog i jetrenog kolesterola te na manjak utjecaja na koncentracije metabolita kolesterola u krvnoj plazmi. Provedena je analiza lokalne parametarske osjetljivosti u kojoj se crijevni kolesterol pokazao kao najosjetljivija varijabla, a parametri jetrene sinteze nascentnog HDL-a i nastanka VLDL kolesterola iz jetrenog kolesterola pokazali su najveći utjecaj na izlazne rezultate nakon simulacije modela.
Abstract (english)
Analysis of cholesterol metabolism model was performed using the CellDesigner software. Simulations of the constructed model were conducted using different initial values of dietary cholesterol, obtained from three different menus created for the purposes of thesis – vegetarian diet menu, balanced diet menu and keto diet menu. Model successfully simulates metabolism of cholesterol and its metabolites. Results show that mass of dietary cholesterol has an impact on masses of intestinal and hepatic cholesterol, but not on the concentrations of cholesterol metabolites in the blood plasma. Based on the analysis of local parameter sensitivity it was concluded that intestinal cholesterol is the most sensitive variable of the model. Parameters defining hepatic nascent HDL synthesis and VLDL cholesterol formation were shown to have the greatest impact on the results of the simulation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:576332
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-05-21 08:26:37