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master's thesis
Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:244646
Tomšić, Filip
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Biochemical Engineering
Laboratory for Biochemical Engineering, Industrial Microbiology and Malting and Brewing Technology

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Tomšić, F. (2023). Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE) (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:244646

Tomšić, Filip. "Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:244646

Tomšić, Filip. "Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:244646

Tomšić, F. (2023). 'Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 11 July 2024, https://urn.nsk.hr/urn:nbn:hr:159:244646

Tomšić F. Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 July 11] Available at: https://urn.nsk.hr/urn:nbn:hr:159:244646

F. Tomšić, "Karakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:244646

Metadata
TitleKarakterizacija onečišćenja i optimizacija procesa proizvodnje Etil 5-(piperazin-1-il) benzoforan-2-karboksilata (PBCE)
Title (english)Impurity characterization and process optimisation of the production of ethyl 5-(piperazin-1-yl) benzofuran-2-carboxylate (PBCE)
AuthorFilip Tomšić
MentorBožidar Šantek (mentor)
Committee memberBlaženka Kos (predsjednik povjerenstva)
Committee memberMario Novak (član povjerenstva)
Committee memberAntonija Trontel (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Biochemical Engineering)
(Laboratory for Biochemical Engineering, Industrial Microbiology and Malting and Brewing Technology)
Zagreb
Defense date and country2023-12-22, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Vilazodone je farmaceutski pripravak s primjenom u liječenju kliničke depresije. Prilikom sinteze Etil 5-(piperazin-1-il) benzofuran-2-karboksilata (PBCE), jednog od ishodišnih spojeva u sintezi Vilazodona zamijećena je prisutnost nepoznatog onečišćenja RRT 1,37. U sklopu ovog diplomskog rada provedena je sinteza, izolacija i karakterizacija prije spomenutog onečišćenja, kao i ispitivanje procesnih parametara na tijek i konačne produkte reakcije. Natrijev karbonat korišten je u reakcijama priprave PBCE kao baza, dok je u reakcijama sinteze onečišćenja kao baza korišten trietilamin. Čistoća izoliranih spojeva određena je HPLC analizom, a na temelju LC-MS analize i NMR spektroskopije potvrđena je struktura onečišćenja.
Abstract (english)
Vilazodone is a pharmaceutical drug used in the treatment of clinical depression. During the synthesis of ethyl 5-(piperazin-1-yl) benzofuran-2-carboxylate (PBCE), a precursor in the synthesis of Vilazodone, an unknown impurity with a relative retention time of 1,37 was detected. In this graduate thesis, synthesis, isolation and characterization of the impurity RRT 1,37 was performed. Furthermore, the assaying of the influence of the reaction process paramteres on the course of the reaction and final reaction products was carried out. Sodium carbonate was used as a deprotonating base in the PBCE synthesis reactions, while the triethylamine was used as a deprotonating base for the synthesis of the impurity RRT 1,37. The purity of the isolated products was confirmed using HPLC method. Spectral analysis of the impurity was carried out using LCMS and NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:244646
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-06-04 08:58:17