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doctoral thesis
Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:343019
Mandura Jarić, Ana
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Food Engineering
Laboratory for Chemistry and Technology of Carbohydrates and Confectionery Products

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Mandura Jarić, A. (2024). Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.) (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:343019

Mandura Jarić, Ana. "Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:343019

Mandura Jarić, Ana. "Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)." Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:343019

Mandura Jarić, A. (2024). 'Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)', Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 29 March 2025, https://urn.nsk.hr/urn:nbn:hr:159:343019

Mandura Jarić A. Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.) [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2025 March 29] Available at: https://urn.nsk.hr/urn:nbn:hr:159:343019

A. Mandura Jarić, "Karakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)", Doctoral thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:343019

Metadata
TitleKarakterizacija biološke aktivnosti i formuliranje inkapsuliranih sustava feniletanoidnih glikozida trave ive (Teucrium montanum L.)
Title (english)Characterisation of the biological activity and formulation of encapsulated systems of phenylethanoid glycosides from mountain germander (Teucrium montanum L.)
AuthorAna Mandura Jarić
MentorDraženka Komes (mentor)
Committee memberKsenija Durgo (predsjednik povjerenstva)
Committee memberAleksandra Vojvodić Cebin (član povjerenstva)
Committee memberMarin Roje (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Food Engineering)
(Laboratory for Chemistry and Technology of Carbohydrates and Confectionery Products)
Zagreb
Defense date and country2024, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Universal decimal classification
(UDC)		663 - Industrial microbiology. Industrial mycology. Zymurgy, fermentation industry. Beverage industry. Stimulant industry
Abstract
U radu je provedena valorizacija polifenolnog ekstrakta trave ive (Teucrium montanum) karakterizacijom biološke aktivnosti i formuliranjem inkapsuliranih dozirnih sustava, inkorporiranih u formulacije funkcionalnih bombonskih proizvoda. U tu svrhu, implementirane su ekstrakcijske i inkapsulacijske tehnike te biološki test sustavi uz odgovarajuću analitičku metodologiju. U ekstraktima trave ive u najvećim udjelima identificirani su ehinakozid, teupoliozid, stahizozid A, poliumozid i verbaskozid.... More In vitro ispitivanjima na CAL-27, HepG2, Caco-2 i AGS staničnim linijama (0,025, 0,050, 0,150 i 0,500 mg ekstrakta mLˉ¹), utvrđen je statistički značajan (p<0,05), o koncentraciji ovisan antioksidacijski učinak, kao i genoprotektivan učinak koncentracije 0,500 mg mLˉ¹ na modelnom DNK plazmidu (p<0,05). Na in vivo modelu, utvrđen je statistički značajan (p<0,05) antioksidacijski učinak na stanice jetre, odnosno genoprotektivan učinak na stanice krvi pri svim koncentracijama ekstrakta (250, 500 i 1000 mg kgˉ¹). Inkapsulati formulirani sušenjem raspršivanjem na bazi arapske gume, guar gume i karboksimetil celuloze te nanovlakna dobivena elektroispredanjem na bazi pululana, kolagena, zeina i proteina konoplje, rezultirali su inkapsulacijskom učinkovitosti feniletanoidnih glikozida većom od 72 %, dok je dodatak karboksimetil celuloze, zeina i proteina konoplje usporio kinetiku otpuštanja polifenolnih spojeva u in vitro simuliranim uvjetima probave. Inkorporacijom inkapsulata, razvijeno je pet formulacija inovativnih veganskih žele proizvoda visoko obogaćenih feniletanoidnim glikozidima iz ekstrakta trave ive (Σ 1,2 mg gˉ¹) te poželjnih senzorskih i teksturalnih karakteristika. Less
Abstract (english)
In this study, the valorization of mountain germander (MG) polyphenolic extract (Teucrium montanum) was carried out through the characterisation of biological activity and delivery systems formulation for the incorporation into functional jellies. For this purpose, extraction and encapsulation techniques, biological test systems with appropriate analytical methodology were used. Echinacoside, teupolioside, stachysoside A, poliumoside and verbascoside were identified in the highest yields. In... More vitro analysis on CAL-27, HepG2, Caco-2 and AGS (0.025, 0.050, 0.150 and 0.500 mg extract mLˉ¹) revealed a statistically significant (p<0.05), concentration-dependent antioxidant effect as well as genoprotective effect on DNA plasmid (0.500 mg mLˉ¹). In the in vivo model, a statistically significant (p<0.05) antioxidant effect on the liver, and genoprotective effect on blood, was observed for all extract concentrations (250, 500 and 1000 mg kgˉ¹). Spray-dried particles based on gum arabic, guar gum and carboxymethyl cellulose (CMC), and electrospun nanofibers with pullulan, collagen, zein (ZE) and hemp protein (HP), exhibited encapsulation efficiency of the phenylethanoid glycosides (PGs) over 72 %, while the addition of CMC, ZE and HP enabled sustained polyphenolic release kinetics under in vitro conditions. Incorporation of delivery system resulted in five innovative vegan jellies formulations, enriched with PGs from MG extract (Σ 1.2 mg gˉ¹) with desirable sensory and textural properties. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:343019
Promotion2024
Study programmeTitle: Postgraduate PhD Study in Nutrition
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam (doktor/doktorica znanosti, područje biotehničkih znanosti, polje nutricionizam)
Type of resourceText
Extent344 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-06-21 09:33:58
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