prikaz prve stranice dokumenta Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre
  Download
PDF 2.95 MB
master's thesis
Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:640244
Buljan, Ivona
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Buljan, I. (2023). Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:640244

Buljan, Ivona. "Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:640244

Buljan, Ivona. "Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:640244

Buljan, I. (2023). 'Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:640244

Buljan I. Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 September 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:640244

I. Buljan, "Analiza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:640244

Metadata
TitleAnaliza računalnog modela metabolizma fruktoze u razvoju nealkoholne masne bolesti jetre
Title (english)Analysis of the computional model of fructose metabolism in the development of non-alcoholic fatty liver disease
AuthorIvona Buljan
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2023-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
U području nutricionizma, sistemsko proučavanje bioloških sustava omogućuje bolje razumijevanje utjecaja prehrane na zdravlje. Sistemsko pristupanje prehrani omogućuje personalizirane preporuke temeljene na individualnim potrebama, genetskim čimbenicima i specifičnim metaboličkim odgovorima. U ovom radu je prikazan i analiziran matematički model metabolizma fruktoze u programskom paketu CellDesigner. Glavni cilj istraživanja bio je ispitati kako unos različitih obroka, s obzirom na količinu fruktoze, utječe na metabolizam masti povezan s razvojem nealkoholne masne bolesti jetre. Provedene su simulacije modela koristeći različite početne vrijednosti fruktoze pri različitim obrocima (doručak, marenda, ručak, užina i večera). Rezultati ukazuju da povećane koncentracije fruktoze u prehrani doprinose povećanju nakupljanja triglicerida u jetri. Provedena je analiza lokalne parametarske osjetljivosti u kojoj su se gliceraldehid-3-fosfat i piruvat pokazali kao najosjetljivije varijable modela. Model uspješno simulira promjenu koncentracije fruktoze i njenih metabolita.
Abstract (english)
In the field of nutrition, the systemic study of biological systems allows for a better understanding of the impact of nutrition on health. A systemic approach to nutrition enables personalized recommendations based on individual needs, genetic factors and specific metabolic responses. This paper presents and analyzes the mathematical model of fructose metabolism in the CellDesigner software package. The main goal of the research was to examine how the intake of different meals, with regard to the amount of fructose, affects fat metabolism associated with the development of non-alcoholic fatty liver disease. Model simulations were carried out using different initial values of fructose at different meals (breakfast, brunch, lunch, snack and dinner). The results indicate that increased concentrations of fructose in the diet contribute to increased accumulation of triglycerides in the liver. An analysis of local parametric sensitivity was performed, in which glyceraldehyde-3-phosphate and pyruvate proved to be the most sensitive variables of the model. The model successfully simulates the change in the concentration of fructose and its metabolites.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:640244
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-06-21 08:58:32