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master's thesis
Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. urn:nbn:hr:159:617582
Pranjić, Ines
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Pranjić, I. (2023). Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:617582

Pranjić, Ines. "Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:617582

Pranjić, Ines. "Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2023. https://urn.nsk.hr/urn:nbn:hr:159:617582

Pranjić, I. (2023). 'Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 31 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:617582

Pranjić I. Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2023 [cited 2024 December 31] Available at: https://urn.nsk.hr/urn:nbn:hr:159:617582

I. Pranjić, "Simulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:159:617582

Metadata
TitleSimulacija i analiza globalne parametarske osjetljivosti modela razgradnje ugljikohidrata u debelom crijevu
Title (english)Simulation and analysis of global parameter sensitivity of the carbohydrate decomposition model in the colon
AuthorInes Pranjić
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2023-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Pravilnom prehranom organizam se opskrbljuje svim potrebnim nutrijentima koji, kroz različite biokemijske procese, osiguravaju stanicama rast i normalno funkcioniranje. Metabolizam ugljikohidrata pomoću mikrobiote debelog crijeva jedan je od tih procesa čiji se model analizirao u ovome radu. U svrhu toga, razvijena su četiri jelovnika sa različitim početnim koncentracijama laktoze i glukoze. Model je simuliran u vremenskom intervalu od pet dana i pritom je praćena promjena koncentracije laktoze, glukoze, butirata, polisaharida i mikroorganizama koji koriste laktozu i glukozu. Rezultati pokazuju da se promjenom početne koncentracije laktoze značajno mijenjala i dinamika razgradnje laktoze u debelom crijevu čovjeka. Budući da je riječ o biološkom sustavu, provedena je analiza i globalne parametarske osjetljivosti. Kao najosjetljiviji kinetički parametar istaknula se maksimalna specifična brzina hidrolize polisaharida u jednostavne šećere, khyd,z. U pozadini cijele simulacije je tendencija razvoja individualizirane prehrane odnosno, koncepta skrojenog prema prehrambenim potrebama pojedinca.
Abstract (english)
With a proper diet, the body is supplied with all the necessary nutrients that, after undergoing various biochemical processes, ensure the growth and normal functioning of the cells. Carbohydrate metabolism by colon microbiota is one of those processes whose model was analyzed in this thesis. For this purpose, four menus were developed with different initial concentrations of lactose and glucose. The model was simulated in a time interval of five days and the change in the concentration of lactose, glucose, butyrate, polysaccharides and microorganisms that use lactose and glucose was monitored. The results show that by changing the initial concentration of lactose, the dynamics of lactose decomposition in the human colon also changed significantly. Since it is a biological system, an analysis of global parametric sensitivity was also performed. The maximum specific rate of hydrolysis of polysaccharides (khyd,z) stood out as the most sensitive kinetic parameter. In the background of the entire simulation is the tendency to develop individualized nutrition, a concept tailored to the nutritional needs of the individual.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:617582
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-07-02 09:21:20