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undergraduate thesis
Biološka aktivnost ferocenskih spojeva
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:458229
Petrović, Ema
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Petrović, E. (2024). Biološka aktivnost ferocenskih spojeva (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:458229

Petrović, Ema. "Biološka aktivnost ferocenskih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:458229

Petrović, Ema. "Biološka aktivnost ferocenskih spojeva." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:458229

Petrović, E. (2024). 'Biološka aktivnost ferocenskih spojeva', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:458229

Petrović E. Biološka aktivnost ferocenskih spojeva [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:159:458229

E. Petrović, "Biološka aktivnost ferocenskih spojeva", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:458229

Metadata
TitleBiološka aktivnost ferocenskih spojeva
Title (english)Biological activity of ferrocene compounds
AuthorEma Petrović
MentorLidija Barišić (mentor)
MentorMarija Lovrić (komentor)
MentorMarta Žužić (pomoć pri izradi, neposredni voditelj)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2024-07-10, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Peptidomimetici su spojevi koji svojom trodimenzijskom strukturom oponašaju sekundarne strukturne elemente prirodnih peptida i proteina, a odlikuju se boljom biodostupnošću i proteolitičkom stabilnošću. Umetanjem 1,1'-disupstituiranih ferocenskih kalupa u peptidni lanac inducira se tvorba strukture okreta kao i struktura nalik β-nabranim pločama. Ferocen1,1'-diamin kao rigidni kalup omogućava tvorbu intralančanih vodikovih veza kojima se zatvara 14-člani prsten karakterističan za prirodne β-nabrane ploče. Konjugati ferocen-1,1'-diamina s hidrofobnim aminokiselinama valinom (1,4), leucinom(2,5) te fenilalaninom (3, 6) podvrgnuti su testiranju biološke aktivnosti na zdravoj HFF-1 i tumorskoj MCF-7 staničnoj liniji. Testovi su provedeni u in vitro uvjetima pomoću standardizirane MTT metode. Najviši stupanj toksičnosti i sposobnost raspoznavanja tumorskih od zdravih stanica pokazali su L-konjugati ferocen-1,1'- diamina s leucinom (2) i fenilalaninom (3).
Abstract (english)
Peptidomimetics are compounds whose three-dimensional structure mimics the secondary structural elements of natural peptides and proteins. They are characterized by better bioavailability and proteolytic stability. The insertion of a 1,1-disubstituted ferrocene scaffold into a peptide chain induces the formation of a turn and β-sheet-like structure. Ferrocene-1,1'-diamine as a rigid scaffold enables the formation of intrachain hydrogen bonds that allow the formation of 14-membered ring common to native β-sheets. The conjugates of ferrocene-1,1'-diamine with the hydrophobic amino acids valine (1,4), leucine (2,5), and phenylalanine (3,6) were tested for their biological activity on healthy HFF-1 and tumor MCF-7 cell lines. The tests were performed under in vitro conditions using the standardized MTT method. The L-conjugates of ferrocene-1,1'-diamine with the leucine (2) and phenylalanine (3) showed the highest degree of toxicity and the ability to differentiate between tumor and healthy cells.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:458229
Study programmeTitle: Food Technology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka prehrambene tehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-07-18 11:55:10