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master's thesis
Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:175453
Beneti, Iva
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Beneti, I. (2024). Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:175453

Beneti, Iva. "Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:175453

Beneti, Iva. "Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:175453

Beneti, I. (2024). 'Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 03 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:175453

Beneti I. Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2024 September 03] Available at: https://urn.nsk.hr/urn:nbn:hr:159:175453

I. Beneti, "Simulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:175453

Metadata
TitleSimulacija modela signalnog puta metabolizma inzulina primjenom jelovnika s različitim udjelima ugljikohidrata
Title (english)Simulation of metabolic insulin signaling pathway model based on menus with different proportions of carbohydrates
AuthorIva Beneti
MentorAna Jurinjak Tušek (mentor)
Committee memberJasenka Gajdoš Kljusurić (predsjednik povjerenstva)
Committee memberMaja Benković (član povjerenstva)
Committee memberIvana Rumora Samarin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2024-03-20, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Sistemska biologija u nutricionizmu omogućava bolje razumijevanje utjecaja hrane i njezinih komponenti na zdravlje i pojavu bolesti. U ovom radu provedena je simulacija modela signalnog puta metabolizma primjenom jelovnika s različitim udjelom ugljikohidrata (ketogeni, visokougljikohidratni, mediteranski i jelovnik za povremeni post 16:8) u programskom paketu CellDesigner. Rezultati pokazuju da je kod mediteranskog jelovnika zastupljenost ugljikohidrata najveća u zajutraku i večeri dok se kod visokougljikohidratnog jelovnika najveće količine ugljikohidrata nalaze u doručku i ručku, a kod povremenog posta u ručku. Nadalje rezultati simulacija pokazuju nagli porast koncentracije inzulina na početku kao odgovor na povišenje glukoze u krvi. Udio GLUT4 translokacija raste tijekom vremena, obrnuto proporcionalno promjeni koncentracije inzulina. Može se zaključiti da što su veće početne koncentracije inzulina, to je potrebno više vremena da se veže na receptore neovisno o vrsti jelovnika.
Abstract (english)
Systemic biology in nutrition enhances the understanding of food and its components' impact on health and disease occurrence. In this study, a simulation of the metabolic pathway model using dietary plans with different carbohydrate content (ketogenic, high-carbohydrate, Mediterranean, and intermittent fasting 16:8 menu) was performed using the CellDesigner program package. Results indicate that in the Mediterranean menu, carbohydrate prevalence is highest at breakfast and dinner, while in the highcarbohydrate plan, the highest amounts are found at snack and lunch, and in the intermittent fasting plan, at lunch. Simulations showed a rapid insulin concentration increase initially in response to blood glucose elevation. The proportion of GLUT4 translocation increases over time, inversely proportional to changes in insulin concentration. It can be concluded that higher initial insulin concentrations require more time for their binding to receptors, regardless of the type of dietary plan.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:175453
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-07-25 10:04:26