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master's thesis
Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:340950
Vukšić, Lucija
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Vukšić, L. (2024). Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:340950

Vukšić, Lucija. "Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:340950

Vukšić, Lucija. "Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:340950

Vukšić, L. (2024). 'Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 11 March 2025, https://urn.nsk.hr/urn:nbn:hr:159:340950

Vukšić L. Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2025 March 11] Available at: https://urn.nsk.hr/urn:nbn:hr:159:340950

L. Vukšić, "Priprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:340950

Metadata
TitlePriprava i spektralna analiza biokonjugata ferocena i C6-derivata 2-tiouracila poveznih 1,2,3-triazolom
Title (english)Preparation and spectral analysis of bioconjugate of ferrocene and C6- derivatives of 2-thiouracil connected with 1,2,3-triazole
AuthorLucija Vukšić
MentorSenka Djaković (mentor)
MentorJasmina Lapić (pomoć pri izradi, neposredni voditelj)
Committee memberJasmina Lapić (predsjednik povjerenstva)
Committee memberIgor Stuparević (član povjerenstva)
Committee memberKristina Radošević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2024-10-25, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Povećani interes za konjugate organometalnih spojeva s biomolekulama potaknuo je istraživanja o njihovoj interakciji kako bi se protumačio mehanizam njihog djelovanja. Biokonjugati ferocena uključili su kopulaciju organometalnog dijela i heterocikličke baze koristeći razne vrste mostova. Izbor fragmenata uglavnom je vođen pristupom što veće raznolikosti strukturnih motiva. Poznato je da ferocen uz ostala svojstva posjeduje stabilnost u biološkim uvjetima i netoksičnost, te su njegovi derivati od sve veće važnosti u medicinskoj kemiji te farmaciji. S druge strane analozi 2-tiouracila supstituirani u C6 položaju pokazuju jako dobru biološku aktivnost pa su iz tog razloga predmetom mnogih istraživanja. Cilj ovog diplomskog rada bio je sinteza potencijalno biološki aktivnih kopulata ferocena i C6-derivata 2- tiouracila uz 1,2,3-triazolnu poveznicu. Sinteza je provedena reakcijom klik kemije, odnosno 1,3- dipolarnom cikloadicijom ferocenskog azida i terminalnog S-alkin-2-tiouracila u prisustvu bakra kao katalizatora. Struktura pripravljenih spojeva biti će analizirana IR i NMR spektroskopijom.
Abstract (english)
The increasing interest in conjugates of organometallic compounds with biomolecules has stimulated research into their interaction in order to understand the mechanism of their action. In ferrocene bioconjugates, an organometallic moiety is coupled with a heterocyclic base via different types of bridges. When selecting the fragments, the main aim is to maximise the diversity of structural motifs. It is known that ferrocene has high biological stability and non-toxicity among other properties, and its derivatives are becoming increasingly important in medicinal chemistry and pharmacy. On the other hand, analogues of 2-thiouracil substituted in the C6 position show very good biological activity, which is why they are the subject of numerous studies. The aim of this thesis was the synthesis of potentially biologically active copulates of ferrocene and C6-derivatives of 2-thiouracil with a 1,2,3-triazole as a linker. The synthesis was carried out by a click chemistry reaction, i.e. 1,3-dipolar cycloaddition of ferrocenazide and terminal S-alkyne-2-thiouracil in the presence of copper as catalyst. The structure of the compounds produced is analysed by IR and NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:340950
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
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Created on2024-11-07 10:22:48