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undergraduate thesis
Priprava disupstituiranog ferocenskog alkohola i alaninola
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:358777
Milković, Katarina
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Milković, K. (2024). Priprava disupstituiranog ferocenskog alkohola i alaninola (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:358777

Milković, Katarina. "Priprava disupstituiranog ferocenskog alkohola i alaninola." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:358777

Milković, Katarina. "Priprava disupstituiranog ferocenskog alkohola i alaninola." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:358777

Milković, K. (2024). 'Priprava disupstituiranog ferocenskog alkohola i alaninola', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:358777

Milković K. Priprava disupstituiranog ferocenskog alkohola i alaninola [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:159:358777

K. Milković, "Priprava disupstituiranog ferocenskog alkohola i alaninola", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:358777

Metadata
TitlePriprava disupstituiranog ferocenskog alkohola i alaninola
Title (english)Synthesis of disubstituted ferrocene alcohol and alaninol
AuthorKatarina Milković
MentorMonika Kovačević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2024-06-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Tvorba malih molekula koje sadržavaju ferocen, a mogu se upotrijebiti kao prekursori za tvorbu većih, kompleksnih i potencijalno biološki aktivnih molekula predstavlja iznimno zanimljivo područje bioorganometalne kemije. Takvi spojevi su i ferocenski alkoholi koji se mogu upotrijebiti za sintezu posebne vrste peptidomimetika- depsipetida. U ovom radu prikazana je sinteza ferocenskog alkohola COOMe-Fn-CH₂OH (3) koji se dobiva iz ferocenske ester-kiseline selektivnom redukcijom karboksilne skupine u prisutnosti LiAlH₄. Osim ferocenskog alkohola, za potrebe priprave depsipeptida, pripravljen je alaninol-Boc-Ala-CH₂OH (7). Tehnikama infracrvene spektroskopije te spektroskopije nuklearne magnetske rezonancije, provedena je strukturna analiza pripravljenih alkohola.
Abstract (english)
The formation of small ferrocene-containing molecules that can be used as precursors for the formation of larger, more complex and potentially biologically active molecules is an extremely interesting area of bioorganometallic chemistry. Such compounds include ferrocene alcohols, which can be used for the synthesis of a special type of peptidomimetics - depsipe tides. In this paper, the synthesis of the ferrocene alcohol COOMe-Fn-CH₂OH (3) is presented, which is obtained from ferrocene ester acid by selective reduction of the carboxylic group in the presence of LiAlH₄. In addition to ferrocene alcohol, alaninol- Boc-Ala-CH₂OH (7) was also prepared as potential precursor for depsipeptide synthesis. A spectroscopic analysis of the alcohols produced was carried out using spectroscopic techniques, infrared spectroscopyand nuclear magnetic resonance.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:358777
Study programmeTitle: Biotechnology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-11-08 10:28:55