prikaz prve stranice dokumenta The assessment of the intergenerational effects induced by persistent pollutants on fertility
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master's thesis
The assessment of the intergenerational effects induced by persistent pollutants on fertility
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:731992
Matijević, Dominik
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Biochemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Matijević, D. (2024). The assessment of the intergenerational effects induced by persistent pollutants on fertility (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:731992

Matijević, Dominik. "The assessment of the intergenerational effects induced by persistent pollutants on fertility." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:731992

Matijević, Dominik. "The assessment of the intergenerational effects induced by persistent pollutants on fertility." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:731992

Matijević, D. (2024). 'The assessment of the intergenerational effects induced by persistent pollutants on fertility', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 12 January 2025, https://urn.nsk.hr/urn:nbn:hr:159:731992

Matijević D. The assessment of the intergenerational effects induced by persistent pollutants on fertility [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2025 January 12] Available at: https://urn.nsk.hr/urn:nbn:hr:159:731992

D. Matijević, "The assessment of the intergenerational effects induced by persistent pollutants on fertility", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:731992

Metadata
TitleThe assessment of the intergenerational effects induced by persistent pollutants on fertility
Title (croatian)Procjena međugeneracijskih učinaka postojanih zagađivača na plodnost
AuthorDominik Matijević
MentorIgor Stuparević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Biochemistry)
Zagreb
Defense date and country2024-07-03, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Environmental pollutants, including Cadmium (Cd), Ochratoxin A (OTA), and Perfluorooctanoic acid (PFOA), pose significant threats to reproductive health and genetic stability. This study investigates the effects of these toxicants on mice's reproductive system, focusing on the directly exposed parental generation (F0) and their offspring (F1). Our findings reveal that exposure to Cd, OTA, and PFOA results in significant reproductive toxicity, including reduced spermatozoa numbers and disrupted testosterone levels and gene expression. In the F1 generation, we observed compensatory changes in gene expression related to spermatogenesis and hormone signaling, particularly following PFOA exposure. Epigenetic analyses showed that DNA methylation in sperm of F0 mice correlates with gene expression changes in F1 testis, highlighting the role of epigenetic mechanisms in intergenerational effects. These results revealed the complex interplay between environmental pollutants, epigenetic modifications, and reproductive health across generations, emphasizing the need for stringent regulatory measures and further research to mitigate these risks.
Keywords
Languageenglish
URN:NBNurn:nbn:hr:159:731992
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-11-19 14:11:22