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master's thesis
Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. urn:nbn:hr:159:635859
Ljubas, Jurica
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Ljubas, J. (2024). Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:635859

Ljubas, Jurica. "Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:635859

Ljubas, Jurica. "Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2024. https://urn.nsk.hr/urn:nbn:hr:159:635859

Ljubas, J. (2024). 'Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 11 March 2025, https://urn.nsk.hr/urn:nbn:hr:159:635859

Ljubas J. Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2024 [cited 2025 March 11] Available at: https://urn.nsk.hr/urn:nbn:hr:159:635859

J. Ljubas, "Priprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:159:635859

Metadata
TitlePriprava i spektralna analiza biokonjugata ferocena i derivata ciprofloksacina povezanih 1,2,3-triazolom
Title (english)Preparation and spectral analysis of ferrocene bioconjugates and ciprofloxacin derivatives linked by 1,2,3-triazole
AuthorJurica Ljubas
MentorSenka Djaković (mentor)
MentorJasmina Lapić (pomoć pri izradi, neposredni voditelj)
Committee memberJasmina Lapić (predsjednik povjerenstva)
Committee memberKristina Radošević (član povjerenstva)
Committee memberIgor Stuparević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2024-11-21, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Izvanredno antibakterijsko djelovanje ciprofloksacina, njegova učinkovita farmakokinetika i zanemarive nuspojave doveli su do široke uporabe tog fluorokinolonskog antibiotika. Prekomjerna uporaba ciprofloksacina dovela je do pojave bakterijske rezistencije te je uočena potreba za modifikacijom strukture postojećih fluorokinolona. Ugradnja 1,2,3-triazola kao poveznica između dva farmakofora dovodi do inovativnih bifunkcionalnih lijekova. Cilj ovog diplomskog rada je priprava i spektroskopska analiza potencijalno biološki aktivnih ciprofloksacin-ferocen konjugata 12-17. Ove reakcije provedene su 1,3-dipolarnom cikloadicijom estera propargil-ciprofloksacina 9-11 i ferocenskih azida 6 i 7 korištenjem bakrovog(II) sulfata i natrijeva acetata u dimetilformamidu. Svim pripremljenim spojevima struktura je potvrđena IR i NMR spektroskopijom.
Abstract (english)
The outstanding antibacterial activity of ciprofloxacin, its efficient pharmacokinetics and negligible side effects have led to widespread use of this fluoroquinolone antibiotic. The overuse of ciprofloxacin has led to the emergence of bacterial resistance and the need to change the structure of existing fluoroquinolones has been identified. The incorporation of 1,2,3-triazole as a link between two pharmacophores leads to innovative bifunctional drugs. The aim of this work is to prepare and spectroscopically analyse the potentially biologically active ciprofloxacin-ferrocene conjugates 12-17. These reactions were carried out by 1,3-dipolar cycloaddition of propargyl ciprofloxacin esters 9-11 and ferrocene azides 6 and 7 using copper(II) sulphate and sodium acetate in dimethylformamide. The structure of all prepared compounds was confirmed by IR and NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:635859
Study programmeTitle: Molecular Biotechnology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka molekularne biotehnologije (magistar/magistra inženjer/inženjerka molekularne biotehnologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-11-29 10:04:28