prikaz prve stranice dokumenta Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi
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master's thesis
Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. urn:nbn:hr:159:644529
Juričić, Paula
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Biochemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

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Juričić, P. (2013). Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:644529

Juričić, Paula. "Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:644529

Juričić, Paula. "Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:644529

Juričić, P. (2013). 'Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 07 January 2025, https://urn.nsk.hr/urn:nbn:hr:159:644529

Juričić P. Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2013 [cited 2025 January 07] Available at: https://urn.nsk.hr/urn:nbn:hr:159:644529

P. Juričić, "Utjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:159:644529

Metadata
TitleUtjecaj rapamicina na životni vijek vinske mušice Drosphila melanogaster ovisan o životnoj dobi
Title (english)Age-dependent effect of rapamycin on Drospophila melanogaster lifespan
AuthorPaula Juričić
MentorSlobodan Barbarić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Biochemistry)
Zagreb
Defense date and country2013-12-06, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Brojne studije su pokazale da rapamicin može produljiti životni vijek mnogih organizama. Ciljevi ove studije bili su (i) ispitati utjecaj koncentracije proteina u mediju za uzgoj na duljinu životnog vijeka vinske mušice Drosophile melanogaster, (ii) usporediti utjecaj standardnog nedefiniranog i kemijskog definiranog medija na životni vijek te (iii) utvrditi može li tretman rapamicinom kasnije u životu pozitivno utjecati na životni vijek vinske mušice. Sukladno prethodnim, ovo istraživanje je pokazalo da povećana količina proteina u prehrani negativno utječe na životni vijek vinske mušice. Prema rezultatima, kratkotrajno izlaganje rapamicinu, u trajanju od četiri tjedna, produljuje životni vijek u približno istoj mjeri kao i cjeloživotni tretman. Uz to, rapamicin je smanjio plodnost vinske mušice ali nakon prestanka tretmana rapamicinom, plodnost je vraćena na normalnu razinu.
Abstract (english)
Recent studies demonstrated that chronic rapamycin treatment extends lifespan and reduces fecundity of fruit fly Drosophila melanogaster females. The aim of this thesis was (i) to investigate the effects of increased protein concentration in diet on longevity of the fruit fly, (ii) to compare the effects of standard and chemically defined medium on lifespan and (iii) to determine whether pharmacological intervention with rapamycin late in life have beneficial effects on fly survival. In accordance with others, this study showed that increased protein component of a diet decreases lifespan. It was found that even short rapamycin treatments, of about three weeks, can extend maximum lifespan of a fruit fly to the level comparable to the chronic rapamycin treatment. This effect was observed on all diets tested, suggesting that the effect of rapamycin is at least partially independent of nutrition. Additionally, rapamycin reduced fecundity of females and releasing flies from rapamycin treatment resulted in recovery of fecundity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:644529
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-28 08:45:18