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master's thesis
Razvoj metalopeptida kao katalizatora
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. urn:nbn:hr:159:421209
Aljinović, Zrinka
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Aljinović, Z. (2015). Razvoj metalopeptida kao katalizatora (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:421209

Aljinović, Zrinka. "Razvoj metalopeptida kao katalizatora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:421209

Aljinović, Zrinka. "Razvoj metalopeptida kao katalizatora." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:421209

Aljinović, Z. (2015). 'Razvoj metalopeptida kao katalizatora', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:159:421209

Aljinović Z. Razvoj metalopeptida kao katalizatora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2015 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:159:421209

Z. Aljinović, "Razvoj metalopeptida kao katalizatora", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:159:421209

Metadata
TitleRazvoj metalopeptida kao katalizatora
Title (english)Developing metallopeptides for catalytic applications
AuthorZrinka Aljinović
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2015-04-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Food Technology
Abstract
Mali peptidi koji na svoje bočne ogranke mogu vezati Cu2+ ione pri pH-vrijednostima blizu neutralnih imaju veliki katalitički potencijal. U recentnom istraživanju Iranzo i suradnici sintetizirali su dva peptida, C-Asp i O-Asp, koji pri pH vrijednosti blizu neutralne vežu Cu2+ ione na svoja tri His i jedan Asp aminokiselinski ostatak tvoreći komplekse CuH(C-Asp)]2+ i [CuH(O-Asp)]2+. U ovom je radu sintetiziran novi OdPro-Asp dekapeptid čija je sposobnost koordiniranja Cu2+ iona pri pH-vrijednostima između 5 i 7 proučavana primjenom spektroskopskih tehnika. OdPro-Asp tvori kompleks [CuH(OdPro-Asp)]2+ koji veže Cu2+ ione na isti način kao ranije opisani kompleksi [CuH(C-Asp)]2+ i [CuH(O-Asp)]2+.Mogućnost primjene kompleksâ [CuH(C-Asp)]2+, [CuH(O-Asp)]2+ i [CuH(OdPro-Asp)]2+ kao katalizatora proučavana je korištenjem kvercetina i 3,4-dihidoksibenzojeve kiseline kao supstrata. Pokazalo se da ispitani kompleksi pri pH 6.2 kataliziraju reakcije s kvercetinom, dok katalitička uloga u reakcijama s 3,4-dihidroksibenzojevom kiselinom nije opažena.
Abstract (english)
Short peptides that can bind Cu2+ ions through the side-chain functionalities and generate single species in the neutral pH range may be capable of performing numerous catalytic activities. Recently, Iranzo and co-workers developed two peptides, C-Asp and O-Asp, which bind Cu2+ only to the 3 His and 1 Asp residues at close to neutral pH forming the complexes [CuH(C-Asp)]2+ and [CuH(O-Asp)]2+. Herein, the new decapeptide OdPro-Asp was synthesised and its Cu2+ coordination properties studied using different spectroscopic techniques. The major copper(II) species observed for the OdPro-Asp peptide between pH 5.0 and 7.0 can be described as [CuH(OdPro-Asp)]2+. This species coordinates Cu2+ ions in the same way as the complexes [CuH(C-Asp)]2+ and [CuH(O-Asp)]2+. The possibility of applying the complexes [CuH(C-Asp)]2+, [CuH(O-Asp)]2+ and [CuH(OdPro-Asp)]2+ as catalysts was studied using quercetin and 3,4-dihydroxide benzoic acid as substrates. The complexes reacted with quercetin, but did not react with 3,4-dihidroxide benzoc acid at pH 6.2.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:159:421209
Study programmeTitle: Food Safety Management
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka upravljanja sigurnošću hrane (magistar/magistra inženjer/inženjerka upravljanja sigurnošću hrane)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-02 10:14:08