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master's thesis
Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. urn:nbn:hr:159:092057
Zugan, Sandra
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Food Quality Control
Laboratory for Food Chemistry and Biochemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Zugan, S. (2015). Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:092057

Zugan, Sandra. "Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:092057

Zugan, Sandra. "Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:092057

Zugan, S. (2015). 'Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 08 September 2024, https://urn.nsk.hr/urn:nbn:hr:159:092057

Zugan S. Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2015 [cited 2024 September 08] Available at: https://urn.nsk.hr/urn:nbn:hr:159:092057

S. Zugan, "Antioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:159:092057

Metadata
TitleAntioksidacijski učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na hiperkolesterolemiju u miša
Title (english)Antioxidant effects of bioactive compounds from the extracts of the berry skin of grapes on hypercholesterolemia in mice
AuthorSandra Zugan
MentorIrena Landeka Jurčević (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Food Quality Control)
(Laboratory for Food Chemistry and Biochemistry)
Zagreb
Defense date and country2015-07-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Abstract
Ekstrakt pokožice grožđa obiluje polifenolima - skupinom organskih spojeva koji imaju antioksidacijsko djelovanje, odnosno smanjuju oksidacijski stres. Reciklaža predstavlja odlično ekološko rješenje tretiranja vinskog organskog otpada budući da se godišnje izdvaja tisuću tona pokožice tijekom vinifikacije. U ovom radu istražen je zaštini učinak bioaktivnih spojeva iz ekstrakta pokožice grožđa na oksidacijski stres potaknut hiperlipidnom prehranom u miša. Istraživani biomarkeri oksidacijskog stresa u jetri i bubrezima bili su malonildialdehid (MDA), karbonil proteini (PC), superoksid dismutaza (SOD), katalaza (CAT) i reducirani glutation (GSH). Rezultati pokazuju da je tretman s ekstraktom pokožice grožđa (GSE) u dozi od 100 mg kg-1 tjelesne mase statistički značajno (ANOVA, p<0,05) smanjio aktivnosti PC i MDA u jetri i bubrezima mužjaka i ženki te povećao koncentracije SOD, CAT, GSH u odnosu na kontrolnu skupinu životinja što se može pripisati bioaktivnim spojevima prisutnim u GSE. Dodavanjem ekstrakta pokožice grožđa prehrambenim proizvodima mogla bi se proizvoditi funkcionalna hrana s kardioprotektivnim učinkom.
Abstract (english)
The grape skin extract is rich in polyphenols - a group of organic compounds that have antioxidant activity and thus reduce oxidative stress. Recycling represents an excellent ecological solution for treating vine organic waste since every year over a thousand tons of grape skin is segregated during vinification. In this paper, we studied the effect of protective bioactive compounds from the grape skin extract on oxidative stress induced by high fat diet in mice. Investigated biomarkers of oxidative stress in the liver and kidneys were: malondialdehyde (MDA), protein carbonyl (PC), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH). The results show that the treatment with the grape skin extract (GSE) in a dose of 100 mg kg-1 body weight significantly (ANOVA, p<0,05) reduced the activity of the PC and MDA in the liver and kidneys of both male and female mice, and increased concentrations of SOD, CAT and GSH compared to the control group which can be attributed to the bioactive compounds present in the GSE. By adding grape skin extract to food we could produce functional food with cardioprotective effect.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:092057
Study programmeTitle: Nutrition
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra nutricionizma (magistar/magistra nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-03 08:05:18