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undergraduate thesis
Peptidomimetici kao inhibitori HIV-proteaze
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. urn:nbn:hr:159:960607
Studen, Bosiljka
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Chemistry and Biochemistry
Laboratory for Organic Chemistry

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Studen, B. (2015). Peptidomimetici kao inhibitori HIV-proteaze (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:960607

Studen, Bosiljka. "Peptidomimetici kao inhibitori HIV-proteaze." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:960607

Studen, Bosiljka. "Peptidomimetici kao inhibitori HIV-proteaze." Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2015. https://urn.nsk.hr/urn:nbn:hr:159:960607

Studen, B. (2015). 'Peptidomimetici kao inhibitori HIV-proteaze', Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 01 August 2024, https://urn.nsk.hr/urn:nbn:hr:159:960607

Studen B. Peptidomimetici kao inhibitori HIV-proteaze [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2015 [cited 2024 August 01] Available at: https://urn.nsk.hr/urn:nbn:hr:159:960607

B. Studen, "Peptidomimetici kao inhibitori HIV-proteaze", Undergraduate thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:159:960607

Metadata
TitlePeptidomimetici kao inhibitori HIV-proteaze
Title (english)Peptidomimetics as inhibitors of HIV-protease
AuthorBosiljka Studen
MentorLidija Barišić (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Chemistry and Biochemistry)
(Laboratory for Organic Chemistry)
Zagreb
Defense date and country2015-09-09, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Nutrition
Food Chemistry and Biochemistry
Abstract
Peptidomimetici oponašaju biološku aktivnost prirodnih peptida te unapređuju njhovu selektivnost, biodostupnost i funkcionalnost, zbog čega dizajn i sinteza peptidomimetika predstavljaju važno oruđe u pronalasku lijekova. Virus humane imunodeficijencije (HIV) uzročnik je Sindroma stečene imunodeficijencije (AIDS). Definiranjem strukture i mehanizma djelovanja enzima HIV-proteaze, koji je odgovoran za razvoj virusa HIV-a, dizajniran je niz peptidomimetičkih lijekova kao inhibitora HIV-proteaze. Učinkovitost lijekova prve generacije ovisi o konformaciji aktivnog mjesta enzima, te opada ukoliko dođe do mutacije virusa, što je dovelo do razvoja druge generacije lijekova koji su manje osjetljivi na mutacije virusa. Danas se aktivno radi na dizajnu cikličkih inhibitora koji imaju povećanu potentnost lijeka, poboljšana farmakokinetička svojstva i djelovanje na mutirane sojeve virusa.
Abstract (english)
Peptidomimetics mimic the biological activity of natural peptides with improved selectivity, bioavailability and functionality which makes the design and synthesis of peptidomimetics a valuable tool in finding a cure for different disseasses. Human immunodeficiency virus (HIV) is the causative agent of Acquired Immune Deficiency Syndrome (AIDS). Designe of a series of peptidomimetic drugs, inhibitors of HIV-protease, was enabled by defining the structure and mechanism of action of the HIV-protease, enzyme that is responsible for the development of the HIV virus. The efficiency of the drugs of the first-generation is dependent on the conformation of the active site of the enzyme, and they lose on the inhibitory effect in case of mutation of the virus, leading to the development of second-generation drugs which are less sensitive to mutation of the virus. Today, great effort has been made in the design of cyclic inhibitors which have enhanced potency, improved pharmacokinetic properties and activity for the mutant strains.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:960607
Study programmeTitle: Nutrition
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) nutricionizma)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2015-12-14 10:52:37