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master's thesis
Matematička analiza parametara puta biosinteze ergosterola
Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. urn:nbn:hr:159:439350
Žilić, Hrvoje
University of Zagreb
Faculty of Food Technology and Biotechnology
Department of Process Engineering
Laboratory for Measurement, Regulation and Automatisation

Institutional repository: Repository of the Faculty of Food Technology and Biotechnology

Cite this document

Žilić, H. (2013). Matematička analiza parametara puta biosinteze ergosterola (Master's thesis). Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:159:439350

Žilić, Hrvoje. "Matematička analiza parametara puta biosinteze ergosterola." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:439350

Žilić, Hrvoje. "Matematička analiza parametara puta biosinteze ergosterola." Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, 2013. https://urn.nsk.hr/urn:nbn:hr:159:439350

Žilić, H. (2013). 'Matematička analiza parametara puta biosinteze ergosterola', Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, accessed 07 October 2024, https://urn.nsk.hr/urn:nbn:hr:159:439350

Žilić H. Matematička analiza parametara puta biosinteze ergosterola [Master's thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2013 [cited 2024 October 07] Available at: https://urn.nsk.hr/urn:nbn:hr:159:439350

H. Žilić, "Matematička analiza parametara puta biosinteze ergosterola", Master's thesis, University of Zagreb, Faculty of Food Technology and Biotechnology, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:159:439350

Metadata
TitleMatematička analiza parametara puta biosinteze ergosterola
Title (english)Mathematical parameter analysis of ergosterol biosynthesis pathway
AuthorHrvoje Žilić
MentorŽelimir Kurtanjek (mentor)
GranterUniversity of Zagreb
Faculty of Food Technology and Biotechnology
(Department of Process Engineering)
(Laboratory for Measurement, Regulation and Automatisation)
Zagreb
Defense date and country2013-03-01, Croatia
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Biotechnology
Abstract
Međusobna povezanost puta biosinteze ergosterola i sfingolipida je već dugi niz godina predmet istraživanja. Mnogobrojna novija istraživanja ukazuju na sinergijski učinak ergosterola i sfingolipida. U ovom radu provedena je analiza matematičkog modela biosinteze ergosterola pomoću programskih paketa WR Mathematica 8.0. i CellDesigner 4.3. U model biosinteze ergosterola uključene su reakcije puta biosinteze sfingolipida. Primjenom metoda lokalne i globalne osjetljivosti parametra, identificirani su ključni enzimi matematičkog modela. Rezultati lokalne analize uključuju transport ergosterola u staničnu membranu, uz hidrolize IPC-g i MIPC-g od strane enzima IPCaze, kao najosjetljivije reakcije modela. Kao ključni enzimi prilikom uspostavljanja ustaljenih vrijednosti, ističu se KDHS reduktaza, 4hidroksilaza i ceramid sintaza.
Abstract (english)
Interactions of ergosterol and sphingolipid biosynthesis pathways have been a subject of studies for many years. Numerous new studies indicate synergetic effects between ergosterol and sphingolipids. In this study a mathematical model analysis of ergosterol biosynthesis was performed, using WR Mathematica 8.0. and CellDesigner 4.3 software supports. Ergosterol biosynthesis model includes reaction rates of sphingolipid biosynthesis pathway. By applying local and global parameter sensitivity methods, critical enzymes of the model were identified. Local sensitivity analysis results include ergosterol transport to cellular membrane, along with hydrolosis of IPC-g i MIPC-g as the most sensitive reactions of the model. Upon establishing steady state values, the key enzymes are KDHS reductase, 4hydroxylase and ceramid synthase.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:159:439350
Study programmeTitle: Bioprocess Engineering
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva (magistar/magistra inženjer/inženjerka bioprocesnog inženjerstva)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-05 11:10:15