Continuous growth of human population, combined with the changes in eating habits, calls for an intensification of agricultural production. However, apart from the increase in food production, its nutritional composition is important as well, particularly in terms of microelements. In diets of over two thirds of the world’s population, there is a lack of more than one microelement. Insufficient concentrations of microelements, which are important for proper growth, development and health of humans and domestic animals, can be eliminated with diverse nutrition, microelement supplementation and by increasing the concentration and bioavailability of microelements in feeds used in animal nutrition, or biofortification. By reviewing the literature, the factors that influence the increase in microelement concentration in fodder crops are presented. Agronomic and genetic approach to biofortification is advocated as an immediate strategy to eliminate the lack of microelements most commonly lacking in diets: iron (Fe), copper (Cu), zinc (Zn), iodine (I), selenium (Se). The nutrition of animals containing biofortified fodder aims to increase the concentration of the aforementioned microelements in blood and improve their growth, development and health. By increasing the concentrations of microelements in tissues and milk of domestic animals, the ultimate goal is to meet the microelement needs in humans.