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Scientific paper - Original scientific paper
A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity
Croatica Chemica Acta, 92 (2019), 1; 125-135. https://doi.org/10.5562/cca3527
Bušić, Valentina; Vrandečić, Karolina; Siber, Tamara; Roca, Sunčica; Vikić Topić, Dražen; Gašo Sokač, Dajana

Institutional repository: Repository of the Faculty of Agrobiotechnical Sciences Osijek

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Bušić, V., Vrandečić, K., Siber, T., Roca, S., Vikić Topić, D. & Gašo Sokač, D. (2019). A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity. Croatica Chemica Acta, 92. (1), 125-135. doi: 10.5562/cca3527

Bušić, Valentina, et al. "A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity." Croatica Chemica Acta, vol. 92, no. 1, 2019, pp. 125-135. https://doi.org/10.5562/cca3527

Bušić, Valentina, Karolina Vrandečić, Tamara Siber, Sunčica Roca, Dražen Vikić Topić and Dajana Gašo Sokač. "A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity." Croatica Chemica Acta 92, no. 1 (2019): 125-135. https://doi.org/10.5562/cca3527

Bušić, V., et al. (2019) 'A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity', Croatica Chemica Acta, 92(1), pp. 125-135. doi: 10.5562/cca3527

Bušić V, Vrandečić K, Siber T, Roca S, Vikić Topić D, Gašo Sokač D. A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity. Croatica Chemica Acta [Internet]. 2019 January 28 [cited 2024 December 18];92(1):125-135. doi: 10.5562/cca3527

V. Bušić, K. Vrandečić, T. Siber, S. Roca, D. Vikić Topić and D. Gašo Sokač, "A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity", Croatica Chemica Acta, vol. 92, no. 1, pp. 125-135, January 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:151:435023. [Accessed: 18 December 2024]

Metadata
Title (english)A Rapid Microwave Induced Synthesis of Isonicotinamide Derivatives and their Antifungal Activity
AuthorValentina Bušić
AuthorKarolina Vrandečić
AuthorTamara Siber
AuthorSunčica Roca
AuthorDražen Vikić Topić
AuthorDajana Gašo Sokač
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Agrobiotechnical Sciences Osijek
(Department of Phytomedicine)
Scientific / art field,
discipline and subdiscipline		BIOTECHNICAL SCIENCES
Agronomy
Phytomedicine
Abstract (english)
Ten novel isonicotinamide derivatives were prepared by quaternization reactions of isonicotinamide with methyl iodide and nine differently substituted 2 bromoacetophenones under rapid microwave irradiation of 10 minutes. The microwave preparations were significantly faster and with yields higher up to 8 times, than the preparations by conventional method. The structures of synthesized molecules were determined by one- and two dimensional NMR and IR spectroscopy, mass spectrometry and elemental analysis. Antifungal activity of all compounds was tested in two different concentrations (10 and 100 µg mL–1) against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum in vitro. From the antifungal assay it can be seen that the most prepared compounds have moderate to weak activity against M. phaseolina and F. culmorum. A very high inhibitory rate was observed against S. sclerotiorum, 62–87.5 % in concentration of 10 µg mL–1 and 83.7–93.2 % in concentration of 100 µg mL–1. <br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 92, no. 1, pp. 125-135
p-ISSN0011-1643
e-ISSN1334-417X
DOIhttps://doi.org/10.5562/cca3527
URN:NBNurn:nbn:hr:151:435023
Publication2019-01-28
Document URLhttps://hrcak.srce.hr/222767
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-06-27 10:34:23