Although long-term warfarin was the most commonly used oral anticoagulant, the NOACs (new oral anticoagulants - dabigatran, apixaban and rivaroxaban) are increasingly used instead. Patients' satisfaction with their therapy is important for assessing the impact of satisfaction on quality of life. Validated questionnaires are used for this purpose, and one of these is the DASS questionnaire. Until now, in Croatia, testing of anticoagulants satisfaction with DASS was carried out only for warfarin. The aim of the study was to compare the satisfaction of patients with warfarin and NOAC and link the DASS questionnaires with adherence. The research was conducted from November 2017 to May 2018 with the help of public pharmacies in the area of Zagreb and Slavonski Brod and its surroundings. Patients over the age of 18 who use therapy for more than three months have signed an informed consent and filled out the DASS questionnaire, adherence questionnaire and demographic and clinical information questions. The study included 88 patients, of whom 46 were on warfarin and 42 on NOACs. Of the total number of patients on NOACs, half of the patients had used warfarin before the present therapy. The average DASS sum of all patients in total showed high satisfaction with therapy (56.14 ± 21.79). Patients on NOACs showed statistically significantly greater satisfaction than those on warfarin (p = 0.007). In the category of psychological effects, those who currently use NOAC and have used warfarin earlier have also shown greater sastifaction than those who have not previously used it. There was a statistically significant correlation between bleeding and poorer satisfaction, as much as poorer satisfaction and lower adherence. It is important to realize how patients feel about their therapy and how much they know about it and also connect their satisfaction to certain patient subgroups with regard to demographic and clinical data in order to improve the quality of their life. It is also important to assess the degree of adherence, its impact on therapy, and satisfaction, and identify the reasons for poor adherence so that healthcare professionals know how to act for its improvement.