Objectives: The main objective of this research is to better understand the use of topical drugs during pregnancy and lactation for the most common dermatological manifestations occurring at that time. Newer data on medicines registered in the Croatia have been systematized and their pharmacotherapeutic effect and their effect on pregnancy during pregnancy and / or lactation are briefly described. Clinical trials on pregnant women and nursing mothers are not ethically acceptable, so all data is based on experience, reported adverse reactions, or animal testing, but the most important step is to properly assess the benefit the drug may have and the potential risk for the mother or child. Materials and Methods: The current literature on the use of medicines during pregnancy and lactation, pharmacology textbooks, pharmacotherapeutic manuals, the register of medicines in the Republic of Croatia and the PubMed bibliographic database were used during this work. When searching the PubMed database these keywords were used: topical drugs during pregnancy and lactation, dermatics and pregnancy, skin in pregnancy, skin changes and pregnancy, and the names of certain dermatoses or groups associated with pregnancy and / or lactation. Results: During pregnancy, additional and proper skin and hair care is required. Mild hydrating face creams and body milk are recommended with no paraffin preservative and strong odor. There is no need for sunburn in the sun, and during the exposure it is necessary to wear a hat and apply mineral wrap to the exposed body parts. In most pregnant women, the skin becomes shiny and beautiful, which can be emphasized by proper care. Conclusion: Due to adaptation of the body to changes that occur during pregnancy some skin changes are inevitable. Skin infections are common in the general population, so in pregnant women and breastfeeding, skin pigmentation, most commonly on the face, is a normal occurrence, but it can be intensified by exposure to sunlight, so it is recommended to use protective cream and spontaneously withdraw after birth. Strokes appear in the second half of pregnancy in the area of the abdomen, the hips and the breast due to increased weight and sudden stretching of the skin. There are few substances that will prevent their emergence. Circulation changes, under the skin it increases, resulting in redness in the face, more visible vascular veins on the surface of the skin and hemorrhoids. Hemorrhoid gland intensifies in pregnancy leading to acne, especially in the first trimester, hair and other hair becomes more visible in contrast to postpartum when hair falls. Precisely because it is all intensified during pregnancy, all the preparations applied to the skin are absorbed much more deeply into the deeper layers of the skin, and so is the systemic circulation that gives us more caution.