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master's thesis
Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. urn:nbn:hr:163:878752
Marušić, Ava
University of Zagreb
Faculty of Pharmacy and Biochemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Marušić, A. (2015). Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:878752

Marušić, Ava. "Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:878752

Marušić, Ava. "Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:878752

Marušić, A. (2015). 'Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:878752

Marušić A. Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2015 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:878752

A. Marušić, "Retrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:163:878752

Metadata
TitleRetrospektivna analiza liječenja bolesnika s kroničnim C hepatitisom pegiliranim interferonom i ribavirinom u tercijarnoj zdravstvenoj ustanovi
Title (english)Retrospective cohort study of pegylated interferon and ribavirin in the treatment of hepatitis C in tertiary health care
AuthorAva Marušić
MentorIvica Grgurević (mentor)
Committee memberIvica Grgurević
Committee memberVesna Bačić Vrca
Committee memberMaja Ortner Hadžiabdić
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
Zagreb
Defense date and country2015-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Hepatitis C veliki je javnozdravstveni problem i jedan od glavnih uzroka transplantacije jetre, stoga se pokušava pronaći optimalna terapija za liječenje navedene bolesti. U KB Dubrava u periodu od 2007. do 2013. godine za liječenje kroničnog hepatitis C koristila se dvojna terapija ribavirina i pegiliranog interferona. Tokom navedenog perioda skupljena je skupina od 39 pacijenata čija dokumentacija je prikupljena i obrađena u ovom radu. Iz dostupnih podataka ispitala se zastupljenost genotipova u populaciji te stupanj izlječivosti pojedinih genotipova. Ishod liječenja proučavan je kroz brzi virološki odgovor (vrijednosti HCV 12 tjedana nakon terapije), virološki odgovor na kraju terapije te kroz trajni virološki odgovor (6 mjeseci nakon završetka liječenja). Studija je pokazala da su u populaciji češće bili zastupljeni genotipovi 1 i 4, međutim trajni virološki odgovor postignut je u znatno većem postotku kod genotipova 2 i 3, pa je tako tek 36% pacijenata s genotipom 1 i 4 postiglo trajni virološki odgovor, dok je on kod genotipa 2 i 3 iznosio 64,28%. Nuspojave su bile češće kod starije populacije, a liječenju su pristupali pacijenti s visokom viremijom i značajnom fibrozom. Iako je studija napravljena na samo 39 ispitanika njezini rezultati u skladu su s rezultatima objavljenim u stručnoj literaturi.
Abstract (english)
Hepatitis C is a global health problem. In a period of five years combination of interferon and ribavirin was used in Clinical Hospital Dubrava as a therapy for hepatitis C. This therapy was used by 39 patients in Clinical Hospital Dubrava whose medical documentation was researched in this study. We investigated the most popular genotypes in the population and the efficiency and safety of this therapy. The efficiency of therapy was measured trough the number of people that had sustained viral response. Study shows that genotypes 1 and 4 were more frequent in the population but people with genotypes 2 and 3 had a better response to the treatment. Only 36% of patients with genotypes 1 and 4 and 64.28% of patients with genotypes 2 and 3 had SVR. This therapy had serious side effects such as anemia, pancytopenia, leukocytopenia etc. Due to the side effects some of the patients had to stop using their therapy. Better response to the therapy, with less side effects, was among younger people and among people with lower viral load. Although it includes only 39 patients, this study shows almost the same results as other similar studies that investigates efficiency and safety of interferon and ribavirin therapy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:878752
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-02-11 13:50:05