prikaz prve stranice dokumenta Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom
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master's thesis
Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. urn:nbn:hr:163:042635
Ćaćić, Maja
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmaceutical technology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Ćaćić, M. (2015). Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:042635

Ćaćić, Maja. "Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:042635

Ćaćić, Maja. "Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2015. https://urn.nsk.hr/urn:nbn:hr:163:042635

Ćaćić, M. (2015). 'Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:163:042635

Ćaćić M. Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2015 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:163:042635

M. Ćaćić, "Izrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:163:042635

Metadata
TitleIzrada i karakterizacija micela tiloksapola s uklopljenim deksametazonom
Title (english)Preparation and characterization of tyloxapol micelles loaded with dexamethasone
AuthorMaja Ćaćić
MentorIvan Pepić (mentor)
Committee memberIvan Pepić
Committee memberJasmina Lovrić
Committee memberLovorka Vujić
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Zagreb
Defense date and country2015-07-14, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U ovom radu ispitivana je mogućnost solubilizacije deksametazona kao teško topljive djelatne tvari, neionskog solubilizatora tiloksapola i Krebs-Ringerova pufera kao složene otopine elektrolita, a sve pri temperaturi od 34°C koja je karakteristična za mjesto apsorpcije djelatne tvari. Sadržaj otopljenog/solubiliziranog deksametazona određena je spektrofotometrijski pri =241nm. Topljivost deksametazona se pri koncentracijama tiloksapola manjim od cmc (kritične micelizacijske koncentracije) ne mijenja, a kad koncentracija tiloksapola dosegne koncentracije veće od cmc dolazi do porasta topljivosti što je posljedica micelarne solubilizacije. Veličina i disperznost micela određena je fotonskom korelacijskom spektroskopijom. Ako se usporedi veličina micela tiloksapola i veličina micela tiloksapola sa uklopljenim deksametazonom vidi se da se veličina micela znatno ne mijenja pa se može zaključiti da su nastali micelarni sustavi stabilni.
Abstract (english)
In this study we examined the possibility of solubilization ability of dexamethasone as a sparingly soluble active substance, a nonionic solubilizer tyloxapol and Krebs-Ringer buffer solution as the electrolyte complex, and all at a temperature of 34 ° C which is characteristic for the location of absorption of the drug. The content of dissolved / solubilized dexamethasone was determined spectrophotometrically at  = 241nm. Solubility of dexamethasone at concentrations of tyloxapol which are less than cmc (critical micelizacijske concentration) do not change, and when the concentration reaches tyloxapol concentration greater than cmc, an increase in solubility as a result of micellar solubilization. The size and dispersity of the micelles was determined by photon correlation spectroscopy. If one compares the size of the micelles tyloxapol and size micelles tyloxapol fitted with dexamethasone it can be seen that the size of the micelles did not change so it can be concluded that the resulting micellar systems are stable.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:042635
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2016-02-12 14:40:45