prikaz prve stranice dokumenta Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije
  Download
PDF 907.39 KB
master's thesis
Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:732762
Hršak, Ira
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of pharmacology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Hršak, I. (2019). Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:732762

Hršak, Ira. "Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:732762

Hršak, Ira. "Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:732762

Hršak, I. (2019). 'Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:732762

Hršak I. Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:732762

I. Hršak, "Oreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:732762

Metadata
TitleOreksinski sustav i nove terapijske mogućnosti u liječenju nesanice i narkolepsije
Title (english)Orexin system and new therapeutic possibilites for treatment of insomnia and narcolepsy
AuthorIra Hršak
MentorLidija Bach-Rojecky (mentor)
Committee memberLidija Bach-Rojecky (predsjednik povjerenstva)
Committee memberMaja Ortner Hadžiabdić (član povjerenstva)
Committee memberŽeljka Vanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Zagreb
Defense date and country2019-07-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Oreksinski (hipokretinski) sustav, otkriven prije svega 20 godina, sudjeluje u regulaciji različitih fizioloških procesa i funkcija u organizmu sisavaca. Povezan je s odgovorom na stres, hranjenjem, homeostazom energije i sustavom nagrađivanja, a zbog svoje uključenosti u regulaciju spavanja i budnosti potencijalna je meta za razvoj novih lijekova za nesanicu i narkolepsiju. Za terapiju nesanice proučavaju se antagonisti oreksina. Prvi odobreni antagonist u SAD-u i Japanu bio je suvoreksant. Trenutno je i jedini na tržištu, ali intenzivno se radi na razvoju novih. Za terapiju narkolepsije istražuje se nadomjesna terapija oreksinom te oreksinski agonisti. Ukoliko ispitivanja pokažu učinkovitost, uz prihvatljiv sigurnosni profil, to će biti prvi terapijski pristup koji djeluje na uzrok, a ne primarno na simptome bolesti.
Abstract (english)
The orexin system, discovered twenty years ago, has multiple roles in human body. It is associated with stress responese, feeding behaviour, energy homeostasis and reward system, but because of its important role in sleep and arousal regulation, it is a potential target for the development of new drugs for insomnia and narcolepsy. For insomnia therapy, orexin antagonists are being studied. The first approved orexin antagonist in the USA and Japan was suvorexant. It´s currently the only one on the market, but others are being intensively worked on. For narcolepsy therapy, orexin supstitution and orexin agonists are being observed. If the tests show effectivnes, along with acceptable safety profile, this would be the first therapeutical approach for narcolepsy that would act on the cause and not only the symptoms.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:732762
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-21 15:40:45