prikaz prve stranice dokumenta Biopokazatelji malignih bolesti crijeva
  Download
PDF 625.01 KB
master's thesis
Biopokazatelji malignih bolesti crijeva
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. urn:nbn:hr:163:401901
Brajković, Marija
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medical biochemistry and haematology

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Brajković, M. (2018). Biopokazatelji malignih bolesti crijeva (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:401901

Brajković, Marija. "Biopokazatelji malignih bolesti crijeva." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:163:401901

Brajković, Marija. "Biopokazatelji malignih bolesti crijeva." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:163:401901

Brajković, M. (2018). 'Biopokazatelji malignih bolesti crijeva', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 10 May 2024, https://urn.nsk.hr/urn:nbn:hr:163:401901

Brajković M. Biopokazatelji malignih bolesti crijeva [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2018 [cited 2024 May 10] Available at: https://urn.nsk.hr/urn:nbn:hr:163:401901

M. Brajković, "Biopokazatelji malignih bolesti crijeva", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:163:401901

Metadata
TitleBiopokazatelji malignih bolesti crijeva
Title (english)Malignant bowel biomarkers
AuthorMarija Brajković
MentorKarmela Barišić (mentor)
Committee memberKarmela Barišić (predsjednik povjerenstva)
Committee memberRoberta Petlevski (član povjerenstva)
Committee memberŽeljka Vanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medical biochemistry and haematology)
Zagreb
Defense date and country2018-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Kolorektalni karcinom jest zloćudna novotvorina epitelnih stanica sluznice debelog crijeva. Spada u skupinu tumora s najvećom incidencijom i visokom stopom smrtnosti. Razvoj kolorektalnog karcinoma potiču stanične promjene genske ekspresije i sinteze proteina. Pogreške u genomu matične stanice česte su kod kolorektalnog karcioma, a postoje tri različita aspekta genomske nestabilnosti: CIN, MSI i putevi fenotipa CpG. Promjene se događaju na genima za proteine vezane za diobu matičnih stanica AURK i Plk. Također vrlo česte su pogreške i na tumor supresorskim genima TP53, DCC i APC. Osim gena za rast stanice narušeni su i menhanizmi za regulaciju stanične diferencijacije i stanične signalizacije, a osobito Ras-Raf-MAPK puta. Proteinski biopokazatelji se najčešče koriste za otkrivanje i dijagnozu tumora debelog crijeva, te praćenje tijeka bolesti, a najistaknutiji su CEA, CA 19-9, MMP9 i NGAL. Biopokazatelji olakšavaju dijagnozu bolesti, propisivanje terapije i meta su novih terapijskih sustava.
Abstract (english)
Colorectal cancer is a malignant neoplasm of epithelial cells of the colon. It belongs to the tumor group with the highest incidence and high mortality rate. The development of colorectal cancer promotes cellular gene expression and protein synthesis. Genome defects are common in colorectal cancer, and there are three different aspects of genomic instability: CIN, MSI and CpG phenotype pathways. Changes occur on protein genes related to the division of the stem cells AURK and Plk. Also very common are faults in tumor suppressor genes TP53, DCC and APC. In addition to cell growth genes, there are also maladies to regulate cell differentiation and cellular signaling, especially Ras-RafMAPK pathways. Protein biomarkers are most commonly used to detect and diagnose colon cancer and disease tracking and CEA, CA 19-9, MMP9 and NGAL are most prominent. Biomarkers facilitate disease diagnosis, prescribing therapy and targeting new therapeutic systems.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:401901
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-21 16:20:16