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master's thesis
Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:834148
Morić, Sandra
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Morić, S. (2019). Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:834148

Morić, Sandra. "Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:834148

Morić, Sandra. "Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:834148

Morić, S. (2019). 'Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:834148

Morić S. Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:163:834148

S. Morić, "Utjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:834148

Metadata
TitleUtjecaj strukturnih značajki antitumorskih inhibitora histon deacetilaze
Title (english)Effect of structural features of antitumor histone deacetylase inhibitors
AuthorSandra Morić
MentorMilena Jadrijević-Mladar Takač (mentor)
Committee memberMilena Jadrijević-Mladar Takač (predsjednik povjerenstva)
Committee memberIrena Žuntar (član povjerenstva)
Committee memberMonika Barbarić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2019-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
U okviru ovog diplomskog rada istražen je odnos fizičko-kemijskih svojstva i parametara toksičnosti odabranih antitumorskih inhibitora (n=31) histon deacetilaza (HDACi) koji sadrže hidroksamsku skupinu, te su provedene QSAR korelacijske studije korištenjem molekulskih deskriptora i ADMET svojstava u svrhu procjene potencijalne toksičnosti i sigurne terapijske primjene ovih inhibitora. Rezultati istraživanja su pokazali da se molekulski deskriptori i ADMET svojstva mogu uspješno primijeniti u predviđanju potencijalnih toksičnih učinaka ispitivanih HDAC inhibitora.
Abstract (english)
In the frame of this diploma work, the relationship between physico-chemical properties and toxicity parameters of selected anti-tumor HDAC inhibitors (n = 31) that contain a hydroxamic acid moiety were investigated and the QSAR correlation studies were performed using molecular descriptors and ADMET properties to evaluate the potential toxicity and safety profile of the therapeutic application of these inhibitors. The results of these studies revealed that the use of molecular descriptors and ADMET parameters can be successfully applied in prediction of the potential toxic effects of investigated HDACIs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:834148
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-24 08:41:15