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master's thesis
Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina
Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. urn:nbn:hr:163:341574
Penić, Anamarija
University of Zagreb
Faculty of Pharmacy and Biochemistry
Department of medicinal chemistry

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Penić, A. (2019). Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina (Master's thesis). Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:341574

Penić, Anamarija. "Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:341574

Penić, Anamarija. "Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina." Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, 2019. https://urn.nsk.hr/urn:nbn:hr:163:341574

Penić, A. (2019). 'Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina', Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:163:341574

Penić A. Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Pharmacy and Biochemistry; 2019 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:163:341574

A. Penić, "Sinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina", Master's thesis, University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:163:341574

Metadata
TitleSinteza i karakterizacija asimetričknih fumardiamida primakina i halogenanilina
Title (english)Synthesis and characterisation of asymmetric primaquine and halogenaniline fumardiamides
AuthorAnamarija Penić
MentorZrinka Rajić (mentor)
Committee memberZrinka Rajić (predsjednik povjerenstva)
Committee memberHrvoje Rimac (član povjerenstva)
Committee memberJasna Jablan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Zagreb
Defense date and country2019-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract
Reakcija adicije nukleofila na C=C dvostruku vezu koja je susjedna karbonilnoj C=O skupini zove se konjugirana adicija, Michaelova adicija ili 1,4-adicija. Reaktanti u Michaelovoj adiciji još se nazivaju Michaelovi donori i Michaelovi akceptori. Michaelove akceptore nalazimo u sljedećim skupinama lijekova: citostatici - inhibitori EGFR-a, te inhibitori Brutonove tirozin-kinaze, potom antiparkinsonici, lijekovi za terapiju multiple skleroze (dimetil-fumarat) i diuretici (etakrinska kiselina). U ovom radu opisana je sinteza potencijalnih Michaelovih akceptora, asimetričnih fumardiamida primakina i halogenanilina 4a-d. Novi spojevi karakterizirani su uobičajenim metodama (MS, IR, 1H i 13C NMR). Ispitivanje njihovog biološkog djelovanja je u tijeku
Abstract (english)
Nucleophilic addition to a C=C double bond immediately adjected to the C=O group is called conjugate addition, Michael addition or 1,4-addition. The reactants in Michaels addition are commonly known as Michael acceptors and Michael donors. Michael acceptors are present in the following drug classes: cytostatics – EGFR inhibitors and Bruton′s tyrosine kinase inhibitors , antiparkinsonics , drug for the therapy of multiple sclerosis and diuretics . Here we present synthesis of potential Michael acceptors, asymmetric primaquine and halogenaniline fumardiamides 4a-d. All new compounds were characterized by standard methods (MS, IR, 1H and 13C NMR). The evaluation of their biological activity is in progress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:163:341574
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-02-28 12:55:04