prikaz prve stranice dokumenta Antiproliferative evaluation of various aminoquinoline derivatives
  Download
PDF 350.24 KB
Scientific paper - Original scientific paper
Antiproliferative evaluation of various aminoquinoline derivatives
Acta Pharmaceutica, 69 (2019), 4; 661-672. https://doi.org/10.2478/acph-2020-0048
Zorc, Branka; Rajić, Zrinka; Perković, Ivana

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Zorc, B., Rajić, Z. & Perković, I. (2019). Antiproliferative evaluation of various aminoquinoline derivatives. Acta Pharmaceutica, 69. (4), 661-672. doi: 10.2478/acph-2020-0048

Zorc, Branka, et al. "Antiproliferative evaluation of various aminoquinoline derivatives." Acta Pharmaceutica, vol. 69, no. 4, 2019, pp. 661-672. https://doi.org/10.2478/acph-2020-0048

Zorc, Branka, Zrinka Rajić and Ivana Perković. "Antiproliferative evaluation of various aminoquinoline derivatives." Acta Pharmaceutica 69, no. 4 (2019): 661-672. https://doi.org/10.2478/acph-2020-0048

Zorc, B., Rajić, Z. and Perković, I. (2019) 'Antiproliferative evaluation of various aminoquinoline derivatives', Acta Pharmaceutica, 69(4), pp. 661-672. doi: 10.2478/acph-2020-0048

Zorc B, Rajić Z, Perković I. Antiproliferative evaluation of various aminoquinoline derivatives. Acta Pharmaceutica [Internet]. 2019 [cited 2024 December 23];69(4):661-672. doi: 10.2478/acph-2020-0048

B. Zorc, Z. Rajić and I. Perković, "Antiproliferative evaluation of various aminoquinoline derivatives", Acta Pharmaceutica, vol. 69, no. 4, pp. 661-672, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:918336. [Accessed: 23 December 2024]

Metadata
Title (english)Antiproliferative evaluation of various aminoquinoline derivatives
AuthorBranka Zorc
AuthorZrinka Rajić
AuthorIvana Perković
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f, primaquine bis-ureas 2a–f, chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 69, no. 4, pp. 661-672
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2020-0048
URN:NBNurn:nbn:hr:163:918336
Publication2019
Document URLhttps://hrcak.srce.hr/221405
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-07 15:19:20