prikaz prve stranice dokumenta Chloroquine urea derivatives: synthesis and antitumor activity in vitro
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Scientific paper - Original scientific paper
Chloroquine urea derivatives: synthesis and antitumor activity in vitro
Acta Pharmaceutica, 68 (2018), 4; 471-483. https://doi.org/10.2478/acph-2018-0039
Pavić, Kristina; Rajić, Zrinka; Mlinarić, Zvonimir; Uzelac, Lidija; Kralj, Marijeta; Zorc, Branka

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Pavić, K., Rajić, Z., Mlinarić, Z., Uzelac, L., Kralj, M. & Zorc, B. (2018). Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharmaceutica, 68. (4), 471-483. doi: 10.2478/acph-2018-0039

Pavić, Kristina, et al. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica, vol. 68, no. 4, 2018, pp. 471-483. https://doi.org/10.2478/acph-2018-0039

Pavić, Kristina, Zrinka Rajić, Zvonimir Mlinarić, Lidija Uzelac, Marijeta Kralj and Branka Zorc. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica 68, no. 4 (2018): 471-483. https://doi.org/10.2478/acph-2018-0039

Pavić, K., et al. (2018) 'Chloroquine urea derivatives: synthesis and antitumor activity in vitro', Acta Pharmaceutica, 68(4), pp. 471-483. doi: 10.2478/acph-2018-0039

Pavić K, Rajić Z, Mlinarić Z, Uzelac L, Kralj M, Zorc B. Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharmaceutica [Internet]. 2018 [cited 2024 December 23];68(4):471-483. doi: 10.2478/acph-2018-0039

K. Pavić, Z. Rajić, Z. Mlinarić, L. Uzelac, M. Kralj and B. Zorc, "Chloroquine urea derivatives: synthesis and antitumor activity in vitro", Acta Pharmaceutica, vol. 68, no. 4, pp. 471-483, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:361119. [Accessed: 23 December 2024]

Metadata
Title (english)Chloroquine urea derivatives: synthesis and antitumor activity in vitro
AuthorKristina Pavić
AuthorZrinka Rajić
AuthorZvonimir Mlinarić
AuthorLidija Uzelac
AuthorMarijeta Kralj
AuthorBranka Zorc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
In the current paper, we describe design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of the urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity in micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide insight into the design of new anticancer agents.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 68, no. 4, pp. 471-483
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2018-0039
URN:NBNurn:nbn:hr:163:361119
Publication2018
Document URLhttps://hrcak.srce.hr/203273
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-07 15:49:49