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Scientific paper - Preliminary note / Short communication
N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora
Acta Pharmaceutica, 58 (2008), 2; 231-236. https://doi.org/10.2478/v10007-008-0010-7
Matijević-Sosa, Julija; Samaržija, Ita; Honović, Lorena; Jurišić, Blaženka

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Matijević Sosa, J., Samaržija, I., Honović, L. & Jurišić, B. (2008). N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora. Acta Pharmaceutica, 58. (2), 231-236. doi: 10.2478/v10007-008-0010-7

Matijević Sosa, Julija, et al. "N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora." Acta Pharmaceutica, vol. 58, no. 2, 2008, pp. 231-236. https://doi.org/10.2478/v10007-008-0010-7

Matijević Sosa, Julija, Ita Samaržija, Lorena Honović and Blaženka Jurišić. "N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora." Acta Pharmaceutica 58, no. 2 (2008): 231-236. https://doi.org/10.2478/v10007-008-0010-7

Matijević Sosa, J., et al. (2008) 'N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora', Acta Pharmaceutica, 58(2), pp. 231-236. doi: 10.2478/v10007-008-0010-7

Matijević Sosa J, Samaržija I, Honović L, Jurišić B. N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora. Acta Pharmaceutica [Internet]. 2008 [cited 2024 December 27];58(2):231-236. doi: 10.2478/v10007-008-0010-7

J. Matijević Sosa, I. Samaržija, L. Honović and B. Jurišić, "N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora", Acta Pharmaceutica, vol. 58, no. 2, pp. 231-236, 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:622805. [Accessed: 27 December 2024]

Metadata
Title (croatian)N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora
Title (english)N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats
AuthorJulija Matijević-Sosa
AuthorIta Samaržija
AuthorLorena Honović
AuthorBlaženka Jurišić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
U cilju pronalaženja novog efikasnog kelatora koji bi mogao poslužiti u liječenju bolesti izazvanih viškom željeza, u ovom je radu ispitano djelovanje N-ftaloil-glicin-hidroksamske kiseline (Phth-Gly-HA) in vivo. Istraživan je utjecaj kelatora na razinu željeza u serumu štakora nakon intraperitonealne primjene vodene otopine Phth-Gly-HA (0,1 mg mL1) jednom dnevno tijekom 7 dana. Kontrolne su životinje primale fiziološku otopinu. Kod mužjaka injektiranje test supstancije (1 mg kg1) uzrokovalo je pad serumskog željeza za 21%. Kod ženki je nakon tretmana (1,5 mg kg1) izmjereno sniženje razine željeza za 35%. Rezultati pokazuju da ispitivana supstanca ima sposobnost kompleksiranja serumskog željeza, pretežno transferinskog, ali da postoji mogućnost mobilizacije željeza i iz feritinskih zaliha.
Abstract (english)
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Preliminary note / Short communication
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 58, no. 2, pp. 231-236
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/v10007-008-0010-7
URN:NBNurn:nbn:hr:163:622805
Publication2008
Document URLhttps://hrcak.srce.hr/22674
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-08 14:14:26