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Scientific paper - Original scientific paper
Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova
Acta Pharmaceutica, 56 (2006), 1; 19-30. urn:nbn:hr:163:540038
Gornik, Olga; Dumić, Jerka; Floegel, Mirna; Lauc, Gordan

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Gornik, O., Dumić, J., Floegel, M. & Lauc, G. (2006). Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova. Acta Pharmaceutica, 56. (1), 19-30. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:540038

Gornik, Olga, et al. "Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova." Acta Pharmaceutica, vol. 56, no. 1, 2006, pp. 19-30. https://urn.nsk.hr/urn:nbn:hr:163:540038

Gornik, Olga, Jerka Dumić, Mirna Floegel and Gordan Lauc. "Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova." Acta Pharmaceutica 56, no. 1 (2006): 19-30. https://urn.nsk.hr/urn:nbn:hr:163:540038

Gornik, O., et al. (2006) 'Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova', Acta Pharmaceutica, 56(1), pp. 19-30. Available at: https://urn.nsk.hr/urn:nbn:hr:163:540038 (Accessed 23 December 2024)

Gornik O, Dumić J, Floegel M, Lauc G. Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova. Acta Pharmaceutica [Internet]. 2006 [cited 2024 December 23];56(1):19-30. Available at: https://urn.nsk.hr/urn:nbn:hr:163:540038

O. Gornik, J. Dumić, M. Floegel and G. Lauc, "Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova", Acta Pharmaceutica, vol. 56, no. 1, pp. 19-30, 2006. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:540038. [Accessed: 23 December 2024]

Metadata
Title (croatian)Glikoznanost - nova smjernica u suvremenom dizajniranju lijekova
Title (english)Glycoscience - a new frontier in rational drug design
AuthorOlga Gornik
AuthorJerka Dumić
AuthorMirna Floegel
AuthorGordan Lauc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (croatian)
Glikani su najrasprostranjeniji i najraznolikiji biopolimeri prisutni u prirodi. Zbog svojih interakcija s fiziološkim receptorima sudjeluju u mnogim ključnim biološkim procesima. Svi ti procesi potencijalna su meta terapeutskih intervencija pa lijekovi bazirani na ugljikohidratima nalaze svoje mjesto u suvremenoj biotehnologiji i farmaceutskoj industriji. Razvojem glikobiologije prevladan je problem sinteze i analize glikana pa su mnogi spojevi bazirani na ugljikohidratnim strukturama trenutno u različitim fazama kliničkih ispitivanja. Ovaj članak predstavlja glikoproteine u novom svjetlu, kao važne biofarmaceutske ciljeve, dajući pregled njihove potencijalne primjene kao terapijskih glikoproteina i proteoglikana, inhibitora upale, lijekova i vakcina u liječenju tumora, inhibitora patogenih mikroorganizama i virusa, te potencijalnih sredstava u liječenju lizosomskih i neuroloških bolesti te transplantacijskih reakcija.
Abstract (english)
Glycans are the most abundant and most diverse biopolymers in nature. Because of their highly specific interactions with physiological receptors, they participate in many crucial biological processes. All these processes are potential targets for therapeutic intervention, and carbohydrate-based drugs are rapidly being taken up by the modern biotechnology and pharmaceutical industry. Recent developments in the field of glycobiology have overcome the problem of glycan analysis and synthesis; and many compounds based on carbohydrates are now in various stages of clinical trials. This article presents glycoproteins in a new light, as an important biopharmaceutical target, giving an overview of their potential use as therapeutic glycoproteins and proteoglycans, inflammation blockers, cancer therapeutics and vaccines, inhibitors of pathogenic microbes, viral inhibitors and potential aids in the treatment of lysosomal diseases, neurological diseases and transplantation rejection.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 56, no. 1, pp. 19-30
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:540038
Publication2006
Document URLhttps://hrcak.srce.hr/4562
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-08 14:27:40