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Scientific paper - Original scientific paper
Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata
Acta Pharmaceutica, 55 (2005), 4; 387-399. urn:nbn:hr:163:209940
Matijević-Sosa, Julija; Cvetnić, Zdenka

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Matijević Sosa, J. & Cvetnić, Z. (2005). Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata. Acta Pharmaceutica, 55. (4), 387-399. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:209940

Matijević Sosa, Julija and Zdenka Cvetnić. "Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata." Acta Pharmaceutica, vol. 55, no. 4, 2005, pp. 387-399. https://urn.nsk.hr/urn:nbn:hr:163:209940

Matijević Sosa, Julija and Zdenka Cvetnić. "Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata." Acta Pharmaceutica 55, no. 4 (2005): 387-399. https://urn.nsk.hr/urn:nbn:hr:163:209940

Matijević Sosa, J. and Cvetnić, Z. (2005) 'Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata', Acta Pharmaceutica, 55(4), pp. 387-399. Available at: https://urn.nsk.hr/urn:nbn:hr:163:209940 (Accessed 27 December 2024)

Matijević Sosa J, Cvetnić Z. Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata. Acta Pharmaceutica [Internet]. 2005 [cited 2024 December 27];55(4):387-399. Available at: https://urn.nsk.hr/urn:nbn:hr:163:209940

J. Matijević Sosa and Z. Cvetnić, "Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata", Acta Pharmaceutica, vol. 55, no. 4, pp. 387-399, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:209940. [Accessed: 27 December 2024]

Metadata
Title (croatian)Antimikrobna aktivnost N-ftaloil-aminokiselinskih hidroksamata
Title (english)Antimicrobial activity of N-phthaloylamino acid hydroxamates
AuthorJulija Matijević-Sosa
AuthorZdenka Cvetnić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of microbiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
Ispitano je djelovanje N-ftaloil-aminokiselinskih hidroksamata 1–3 opće formule C6H4(CO)2N-X-CONHOH (X = aminokiselinski ostatak glicina, -alanina ili D-fenilglicina) na 44 soja Gram-pozitivnih i Gram-negativnih bakterija i 10 vrsta kvasaca. Antibakterijski i antifungalni učinak testiran je postupkom difuzije na hranjivom agaru i standardnom metodom dilucije. Najbolja inhibicija rasta, osobito izražena prema Gram-negativnim bakterijama, utvrđena je za N-ftaloil-D-fenilglicin hidroksamsku kiselinu (3) s najvećom lipofilnošću. Za soj Yersinia enterocolitica O3 minimalna inhibitorna koncentracija (0,008 mg mL–1) potvrđena je inhibicijskom zonom od 30 mm pomoću difuzijskog testa. Hidroksamati inhibiraju rast keliranjem metala PDF enzima kod Gram-pozitivnih i Gram-negativnih bakterija, te LpxC enzima kod Gram-negativnih bakterija. Ftalimido struktura pridonosi inhibiciji, pretpostavlja se, destabilizacijom m-RNA. Antifungalna aktivnost spojeva 1–3 nije osobito izražena.
Abstract (english)
Antibacterial and antifungal activity of N-phthaloylamino acid hydroxamates 1-3 /C6H4(CO)2N-x-CONHOH, x = amino acid residues of glycine, ß-alanine and D-phenylglycine/ was examined against 44 strains of Gram-positive and Gram-negative bacteria, and 10 species of yeasts. The level of antimicrobial effects was established using the in vitro agar assay and the standard broth dilution susceptibility test. N-phthaloyl-D-phenylglycine-hydroxamic acid (3), the substance with the highest lipophilicity (log P), showed the best antibacterial activity, especially against Gram-negative bacteria. Minimum inhibitory concentration of 3 was 0.008 mg mL-1 in the activity against Yersinia enterocolitica O3, confirmed by a large inhibition zone (30 mm) by the diffusion test. Hydroxamates inhibit growth by chelation of PDF enzyme metal in both Gram-positive and Gram-negative bacteria, and LpxC enzyme in Gram-negative enzyme. Phthalimides apear to contribute to inhibition by destabilizing m-RNA. Antifungal activity of substances 1-3 is not very expressed.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 55, no. 4, pp. 387-399
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:209940
Publication2005
Document URLhttps://hrcak.srce.hr/19044
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-08 16:01:55