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Scientific paper - Original scientific paper
Lipofilnost salicilamida
Acta Pharmaceutica, 54 (2004), 2; 91-101. urn:nbn:hr:163:408547
Medić-Šarić, Marica; Mornar, Ana; Jasprica, Ivona

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Medić Šarić, M., Mornar, A. & Jasprica, I. (2004). Lipofilnost salicilamida. Acta Pharmaceutica, 54. (2), 91-101. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:408547

Medić Šarić, Marica, et al. "Lipofilnost salicilamida." Acta Pharmaceutica, vol. 54, no. 2, 2004, pp. 91-101. https://urn.nsk.hr/urn:nbn:hr:163:408547

Medić Šarić, Marica, Ana Mornar and Ivona Jasprica. "Lipofilnost salicilamida." Acta Pharmaceutica 54, no. 2 (2004): 91-101. https://urn.nsk.hr/urn:nbn:hr:163:408547

Medić Šarić, M., Mornar, A. and Jasprica, I. (2004) 'Lipofilnost salicilamida', Acta Pharmaceutica, 54(2), pp. 91-101. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547 (Accessed 25 November 2024)

Medić Šarić M, Mornar A, Jasprica I. Lipofilnost salicilamida. Acta Pharmaceutica [Internet]. 2004 [cited 2024 November 25];54(2):91-101. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547

M. Medić Šarić, A. Mornar and I. Jasprica, "Lipofilnost salicilamida", Acta Pharmaceutica, vol. 54, no. 2, pp. 91-101, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:408547. [Accessed: 25 November 2024]

Metadata
Title (croatian)Lipofilnost salicilamida
Title (english)Lipophilicity study of salicylamide
AuthorMarica Medić-Šarić
AuthorAna Mornar
AuthorIvona Jasprica
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
U radu je dan pregled istraživanja molekularne lipofilnosti na primjeru salicamida. Log P vrijednost određena je eksperimentalnom («shake-flash») metodom i izračunata je pomoću devet različitih računalnih programa koji se temelje na atom/fragmentarnoj metodi, strukturnim parametrima, atom elektrotopologijskim indeksima uz modeliranje putem neuronskih mreža i topologijskim deskriptorima. Statistička obrada dobivenih rezultata pokazala je najbolju korelaciju eksperimentalno dobivene vrijednosti s log P vrijednošću dobivenom računalnim programoma CslogP, koji se temelji na topologijskim deskriptorima i elektrotopologijskim indeksima.
Abstract (english)
Molecular lipophilicity was studied using salicylamide as a model drug. Log P value for the target compound was experimentally determined by the "shake-flask" method and calculated using nine different computer programs based on atom/fragment contributions, structural parameters, atom-type electrotopological-state indices and neural network modeling, and on topological structure descriptors. Our analysis demonstrates good agreement between the experimentally observed log P value of salicylamide and the value calculated by the CSLogP program, based on topological structure descriptors and electrotopological indices.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 54, no. 2, pp. 91-101
p-ISSN1330-0075
e-ISSN1846-9558
URN:NBNurn:nbn:hr:163:408547
Publication2004
Document URLhttps://hrcak.srce.hr/16795
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-09 13:41:00