Psoriasis, besides being a health problem, it affects the quality of life of patients because of its localization on exposed parts of the skin. It most often occurs on the elbows, knees, scalp, palms and soles of the feet, but it can affect any skin location. Psoriasis can be disabling for the person not only because of skin involvement but also because of concomitant joint disease. Psoriasis can be caused by a range of factors, such as: stress, bacterial and viral infections, injury to the skin (Koebner`s phenomenon), UV rays,alcohol, smoking, drugs, etc. There is clinical proflinking stress to exacerbation of psoriasis. Also, the disease itself can generate emotional stress due to the resulting lesions. Psoriasis undoubtedly has a negative impact on the quality of life of patients. A proof of this is the occurrence of mental disorders which are more common in patients with psoriasis in regard to the general population which can lead to social isolation. Today's medicine has a number, to some extent, effective pharmaceutical and non pharmaceutical methods of treatment. Great progress in therapy represents biological drugs that significantly improve the quality of life for people with psoriasis. Despite the development of new groups of medicines, traditional therapy is still of great importance. Fear of serious side effects of traditional drugs can be avoided by setting individualized plan for each patient and careful monitoring.