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Scientific paper - Original scientific paper
High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims
Croatica Chemica Acta, 78 (2005), 3; 393-396. urn:nbn:hr:163:413751
Džijan, Snježana; Primorac, Dragan; Marcikić, Mladen; Anđelinović, Šimun; Sutlović, Davorka; Dabelić, Sanja; Lauc, Gordan

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Džijan, S., Primorac, D., Marcikić, M., Anđelinović, Š., Sutlović, D., Dabelić, S. & Lauc, G. (2005). High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims. Croatica Chemica Acta, 78. (3), 393-396. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:413751

Džijan, Snježana, et al. "High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims." Croatica Chemica Acta, vol. 78, no. 3, 2005, pp. 393-396. https://urn.nsk.hr/urn:nbn:hr:163:413751

Džijan, Snježana, Dragan Primorac, Mladen Marcikić, Šimun Anđelinović, Davorka Sutlović, Sanja Dabelić and Gordan Lauc. "High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims." Croatica Chemica Acta 78, no. 3 (2005): 393-396. https://urn.nsk.hr/urn:nbn:hr:163:413751

Džijan, S., et al. (2005) 'High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims', Croatica Chemica Acta, 78(3), pp. 393-396. Available at: https://urn.nsk.hr/urn:nbn:hr:163:413751 (Accessed 22 November 2024)

Džijan S, Primorac D, Marcikić M, Anđelinović Š, Sutlović D, Dabelić S, and sur.. High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims. Croatica Chemica Acta [Internet]. 2005 [cited 2024 November 22];78(3):393-396. Available at: https://urn.nsk.hr/urn:nbn:hr:163:413751

S. Džijan, et al., "High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims", Croatica Chemica Acta, vol. 78, no. 3, pp. 393-396, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:413751. [Accessed: 22 November 2024]

Metadata
Title (english)High estimated likelihood ratio might be insufficient in a DNA-lead process of identification of war victims
Title (croatian)Visoke vrijednosti omjera vjerojatnosti ne moraju biti dostatne u procesu identifikacije žrtava rata s pomo}u analize DNA
AuthorSnježana Džijan
AuthorDragan Primorac
AuthorMladen Marcikić
AuthorŠimun Anđelinović
AuthorDavorka Sutlović
AuthorSanja Dabelić
AuthorGordan Lauc
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of biochemistry and molecular biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Medical Biochemistry
Abstract (english)
With the advance in typing tools and extraction procedures in recent years, DNA analysis has developed into an amazingly powerful method for forensic analysis. For a number of years, autosomal STR (Short Tandem Repeat) typing has been used as a tool in the process of identification of war victims in Croatia. Although DNA typing is very effective in detecting possible identities of exhumed skeletal remains, this approach bears some risk of false identification. The paper presents the case of a match between skeletal remains and the son and wife of a missing person in 13 STR loci. Even though these skeletal remains also matched in 13 loci the mother of the same missing person, additional genetic testing (Y-chromosome and mitochondrial DNA) unequivocally excluded the proposed identity. Although likelihood ratio is the best measure of the significance of a genetic match between exhumed skeletal remains and relatives of the missing person, the meaning of likelihood ratio is not as clear in database matching as in simple paternity cases and great care is needed to avoid wrong interpretation. To reduce the risk of possible false identifications, in addition to DNA evidence, other types of evidence (such as information about the time, place and other conditions of disappearance), as well as on anthropological and other »classical« forensic data are being used as a »control mechanism« in the DNA-lead process.
Abstract (croatian)
Zahvaljujući stalnom napretku u metodama izolacije i karakterizacije, analiza DNA razvila se u vrlo moćnu metodu forenzičke analize. Već niz godina analizu autosomnih STR regija primjenjuje se kao temeljnu metodu u procesu identifikacije žrtava rata u Hrvatskoj. Iako je analiza DNA vrlo učinkovita u pronalaženju mogućega identiteta ekshumiranih posmrtnih ostataka, ovakav pristup nosi i određeni rizik pogrešne identifikacije. Ovdje je opisan slučaj poklapanja posmrtnih ostataka sa sinom i suprugom nestale osobe u 13 STR lokusa. Iako su se isti posmrtni ostaci također poklapali i s majkom iste nestale osobe u 13 lokusa, dodatnim genetičkim ispitivanjima (Y kromosom i mitohondrijska DNA) nedvojbeno je isključena mogućnost da se radi o toj osobi. Omjer vjerojatnosti najbolji je pokazatelj značajnosti genetičkoga podudaranja skeletnih ostataka i rodbine nestalih osoba, no kad je to podudaranje pronađeno nasumičnim pretraživanjem baze podataka, značaj omjera vjerojatnosti nije tako jasan kao u jednostavnome utvrđivanju očinstva i potreban je velik oprez kako ne bi došlo do njegove pogrešne interpretacije. Radi smanjivanja rizika pogrešne identifikacije, osim na rezultate analize DNA, pri utvrđivanju identiteta velik značaj potrebno je dati i drugim tipovima dokaza (poput vremena, lokacije i uvjeta nestanka) te antropološkim i ostalim »klasičnim« forenzičkim dokazima, kao kontrolnome mehanizmu u procesu identifikacije predvođenom analizom DNA.
Keywords (english)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 78, no. 3, pp. 393-396
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:413751
Publication2005
Document URLhttps://hrcak.srce.hr/48
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-21 16:18:18