prikaz prve stranice dokumenta Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds
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Scientific paper - Original scientific paper
Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds
Croatica Chemica Acta, 73 (2000), 3; 715-731. urn:nbn:hr:163:162702
Lovrek, Monika; Pilepić, Viktor; Uršić, Stanko

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Lovrek, M., Pilepić, V. & Uršić, S. (2000). Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds. Croatica Chemica Acta, 73. (3), 715-731. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:162702

Lovrek, Monika, et al. "Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds." Croatica Chemica Acta, vol. 73, no. 3, 2000, pp. 715-731. https://urn.nsk.hr/urn:nbn:hr:163:162702

Lovrek, Monika, Viktor Pilepić and Stanko Uršić. "Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds." Croatica Chemica Acta 73, no. 3 (2000): 715-731. https://urn.nsk.hr/urn:nbn:hr:163:162702

Lovrek, M., Pilepić, V. and Uršić, S. (2000) 'Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds', Croatica Chemica Acta, 73(3), pp. 715-731. Available at: https://urn.nsk.hr/urn:nbn:hr:163:162702 (Accessed 23 December 2024)

Lovrek M, Pilepić V, Uršić S. Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds. Croatica Chemica Acta [Internet]. 2000 [cited 2024 December 23];73(3):715-731. Available at: https://urn.nsk.hr/urn:nbn:hr:163:162702

M. Lovrek, V. Pilepić and S. Uršić, "Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds", Croatica Chemica Acta, vol. 73, no. 3, pp. 715-731, 2000. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:162702. [Accessed: 23 December 2024]

Metadata
Title (english)Intriguing salt effects in the formation of hydroxamic acids from aldehydes and nitroso compounds
AuthorMonika Lovrek
AuthorViktor Pilepić
MBZ: 200682
AuthorStanko Uršić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of physical chemistry)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Physical Chemistry
Abstract (english)
Addition of inorganic chlorides and perchlorates into the reaction mixture in water leads to a significant increase of the rate constants observed for the formation of <i>N</i>-phenyl hydroxamic acids from nitrosobenzene and formaldehyde or acetaldehyde. The rate enhancements (relative to the reaction rate constant in »pure water«) vary from the 7.4-fold increase observed on addition of 2.0 mol dm<sup>-3</sup> Mg(ClO<sub>4</sub>)<sub>2</sub> into the reaction mixture to the 230.0-fold increase in the case of 2.0 mol dm<sup>-3</sup> of MgCl<sub>2</sub> added. Linear correlation between log <i>k</i><sub>obs</sub> for the formation of the <i>N</i>-phenylformohydroxamic acid from nitrosobenzene and formaldehyde and the concentration of the anion of the salt added has been observed for MgCl<sub>2</sub>, CaCl<sub>2</sub>, LiCl, Mg(ClO<sub>4</sub>)<sub>2</sub> and NaClO<sub>4</sub>, but different correlations were obtained for NaCl, HCl and HClO<sub>4</sub>. The observations are discussed in terms of ion pairing between the unstable cation reaction intermediates and the anion of the salt. The results obtained suggest that stabilization of the unstable cationic reaction intermediate by the formation of an ion pair with the salt anion is of key importance for the formation of hydroxamate from aldehydes and nitrosobenzenes in more concentrated inert salt water Solutions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 73, no. 3, pp. 715-731
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:162702
Publication2000
Document URLhttps://hrcak.srce.hr/132011
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-29 11:21:48