prikaz prve stranice dokumenta Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases
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Scientific paper - Original scientific paper
Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases
Croatica Chemica Acta, 57 (1984), 2; 281-288. urn:nbn:hr:163:415423
Proštenik, Mladen V.; Dumić, Miljenko; Butula, Ivan

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Proštenik, M. V., Dumić, M. & Butula, I. (1984). Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases. Croatica Chemica Acta, 57. (2), 281-288. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:415423

Proštenik, Mladen V., et al. "Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases." Croatica Chemica Acta, vol. 57, no. 2, 1984, pp. 281-288. https://urn.nsk.hr/urn:nbn:hr:163:415423

Proštenik, Mladen V., Miljenko Dumić and Ivan Butula. "Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases." Croatica Chemica Acta 57, no. 2 (1984): 281-288. https://urn.nsk.hr/urn:nbn:hr:163:415423

Proštenik, M. V., Dumić, M. and Butula, I. (1984) 'Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases', Croatica Chemica Acta, 57(2), pp. 281-288. Available at: https://urn.nsk.hr/urn:nbn:hr:163:415423 (Accessed 30 November 2024)

Proštenik MV, Dumić M, Butula I. Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases. Croatica Chemica Acta [Internet]. 1984 [cited 2024 November 30];57(2):281-288. Available at: https://urn.nsk.hr/urn:nbn:hr:163:415423

M. V. Proštenik, M. Dumić and I. Butula, "Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases", Croatica Chemica Acta, vol. 57, no. 2, pp. 281-288, 1984. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:415423. [Accessed: 30 November 2024]

Metadata
Title (english)Chemistry of 1,3-dioxepins. 111. Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes with strong bases
AuthorMladen V. Proštenik
AuthorMiljenko Dumić
AuthorIvan Butula
MBZ: 6372
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Dehydrohalogenation of 5,6-dihalogen-1,3-dioxepanes II with KOH/MeOH or NaOCH3/MeOH under controlled reaction conditions gave mainly 5-halogen-4,7-dihydro-1,3-dioxepines III. Further substitution of vinylic-bromine in III whit KO-t-Bu/tert-BuOH or KOH/MeOH led to corresponding 5-substituted-4,7-dihydro-1,3- -dioxepines some of which underwent spontaneous isomerization to 6,7-dihydro-1,3-dioxepines. Substitution of vinylic-bromine appeared to follow an elimination-addition mechanism with initial formation of an intermediate with a triple bond.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 57, no. 2, pp. 281-288
p-ISSN0011-1643
e-ISSN1334-417X
URN:NBNurn:nbn:hr:163:415423
Publication1984
Document URLhttps://hrcak.srce.hr/194164
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-30 14:46:30