prikaz prve stranice dokumenta Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells
  Download
PDF 223.68 KB
Scientific paper - Original scientific paper
Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells
Arhiv za higijenu rada i toksikologiju, 70 (2019), 4; 310-314. https://doi.org/10.2478/aiht-2019-70-3372
Roje, Željka; Ilić, Krunoslav; Galić, Emerik; Pavičić, Ivan; Turčić, Petra; Stanec, Zdenko; Vinković Vrček, Ivana

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Roje, Ž., Ilić, K., Galić, E., Pavičić, I., Turčić, P., Stanec, Z. & Vinković Vrček, I. (2019). Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells. Arhiv za higijenu rada i toksikologiju, 70. (4), 310-314. doi: 10.2478/aiht-2019-70-3372

Roje, Željka, et al. "Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells." Arhiv za higijenu rada i toksikologiju, vol. 70, no. 4, 2019, pp. 310-314. https://doi.org/10.2478/aiht-2019-70-3372

Roje, Željka, Krunoslav Ilić, Emerik Galić, Ivan Pavičić, Petra Turčić, Zdenko Stanec and Ivana Vinković Vrček. "Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells." Arhiv za higijenu rada i toksikologiju 70, no. 4 (2019): 310-314. https://doi.org/10.2478/aiht-2019-70-3372

Roje, Ž., et al. (2019) 'Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells', Arhiv za higijenu rada i toksikologiju, 70(4), pp. 310-314. doi: 10.2478/aiht-2019-70-3372

Roje Ž, Ilić K, Galić E, Pavičić I, Turčić P, Stanec Z, and sur.. Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells. Arhiv za higijenu rada i toksikologiju [Internet]. 2019 [cited 2024 November 09];70(4):310-314. doi: 10.2478/aiht-2019-70-3372

Ž. Roje, et al., "Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells", Arhiv za higijenu rada i toksikologiju, vol. 70, no. 4, pp. 310-314, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:808161. [Accessed: 09 November 2024]

Metadata
Title (english)Synergistic effects of parabens and plastic nanoparticles on proliferation of human breast cancer cells
Title (croatian)Sinergistički učinak parabena i nanoplastike na proliferaciju humanih stanica raka dojke
AuthorŽeljka Roje
AuthorKrunoslav Ilić
AuthorEmerik Galić
AuthorIvan Pavičić
AuthorPetra Turčić
AuthorZdenko Stanec
AuthorIvana Vinković Vrček
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Many personal care products on the market contain endocrine disrupting chemicals, including parabens. Parabens are well known chemical additives used as preservatives. They have been found in mammary glands and breast cancer tissues. At the same time, the general public is increasingly exposed to plastic micro- and nanoparticles generated during plastic production and waste disposal. Exposure to chemical cocktails is a realistic scenario of high public health interest, in which many types of compounds such as these two may exhibit synergistic or additive adverse effects. This study evaluated the effects of plastic nanoparticles, parabens, and their mixture on the viability and proliferation of two human breast cancer cell lines: MDA-MB 231, which lacks oestrogen receptors, and MCF-7, which expresses these receptors. Parabens increased proliferation of oestrogen-sensitive breast cancer cells, and this effect became synergistic in the presence of plastic nanoparticles. The mechanism behind synergy may be related to the translocation and adsorption properties of nanoplastics, which served as a Trojan horse to expose cells to parabens more efficiently. These preliminary findings support growing evidence warning about the urgent problem of human exposure to combinations of plastic waste and contingent chemicals.
Abstract (croatian)
Većina proizvoda za osobnu njegu na tržištu sadrži kemikalije koje remete rad endokrinoga sustava kao što su parabeni. Primjena takvih proizvoda povećava izloženost opće populacije takvim kemikalijama. Parabeni, dobro poznati aditivi koji se koriste kao konzervansi, otkriveni su u mliječnim žlijezdama i tkivima raka dojke. Osim takvih kemikalija, izloženost plastičnim mikro- i nanočesticama koje nastaju tijekom proizvodnje, uporabe i odlaganja plastičnog otpada velik su zdravstveni i okolišni problem koji treba hitno rješavati. Za pouzdanu procjenu rizika za ljudsko zdravlje, nužno je objasniti ne samo učinke pojedinačnih kemijskih spojeva nego i njihovih mješavina. Istraživanje izloženosti kemijskim koktelima može pružiti podatke o mogućem sinergističkom ili aditivnom učinku kemikalija u takvim koktelima. Cilj ovoga istraživanja bio je procijeniti učinak plastičnih nanočestica, parabena i njihovih koktela na vijabilnost i proliferaciju dviju različitih stanica karcinoma dojke: stanične linije MDA-MB 231 kojoj nedostaju estrogeni receptori i MCF-7 stanica koje izražavaju te receptore. Dobiveni rezultati pokazali su da ni parabeni ni plastične nanočestice, primijenjeni posebno, u ispitivanim koncentracijskim rasponima nisu značajnije promijenili vijabilnost i proliferacijsku aktivnost u stanicama karcinoma dojke. Međutim, parabeni su pojačali proliferacijsku aktivnost stanica osjetljivih na estrogene koja je sinergistički potaknuta prisutnošću plastičnih nanočestica. Mehanizam takva djelovanja može biti povezan s translokacijskim i adsorpcijskim svojstvima nanočestica, koje su poslužile kao vektor za učinkovitije izlaganje stanica parabenima. Protumorska aktivnost na karcinomu dojke može se očekivati kao konačni ishod izloženosti takvom kemijskom koktelu. Ovi preliminarni podatci dragocjeni su dodatak postojećim ranim upozorenjima na novi problem s povećanjem izloženosti ljudi plastičnom otpadu i kemijskim kemikalijama.
Keywords (english)
Keywords (croatian)
Languageenglish
Languagecroatian
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 70, no. 4, pp. 310-314
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.2478/aiht-2019-70-3372
URN:NBNurn:nbn:hr:163:808161
Publication2019
Document URLhttps://hrcak.srce.hr/229439
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-14 12:00:25