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Scientific paper - Original scientific paper
Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom
Arhiv za higijenu rada i toksikologiju, 67 (2016), 1; 19-24. https://doi.org/10.1515/aiht-2016-67-2708
Sirovina, Damir; Oršolić, Nada; Zovko Končić, Marijana; Gregorović, Gordana

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

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Sirovina, D., Oršolić, N., Zovko Končić, M. & Gregorović, G. (2016). Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom. Arhiv za higijenu rada i toksikologiju, 67. (1), 19-24. doi: 10.1515/aiht-2016-67-2708

Sirovina, Damir, et al. "Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom." Arhiv za higijenu rada i toksikologiju, vol. 67, no. 1, 2016, pp. 19-24. https://doi.org/10.1515/aiht-2016-67-2708

Sirovina, Damir, Nada Oršolić, Marijana Zovko Končić and Gordana Gregorović. "Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom." Arhiv za higijenu rada i toksikologiju 67, no. 1 (2016): 19-24. https://doi.org/10.1515/aiht-2016-67-2708

Sirovina, D., et al. (2016) 'Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom', Arhiv za higijenu rada i toksikologiju, 67(1), pp. 19-24. doi: 10.1515/aiht-2016-67-2708

Sirovina D, Oršolić N, Zovko Končić M, Gregorović G. Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom. Arhiv za higijenu rada i toksikologiju [Internet]. 2016 [cited 2024 November 25];67(1):19-24. doi: 10.1515/aiht-2016-67-2708

D. Sirovina, N. Oršolić, M. Zovko Končić and G. Gregorović, "Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom", Arhiv za higijenu rada i toksikologiju, vol. 67, no. 1, pp. 19-24, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:182999. [Accessed: 25 November 2024]

Metadata
Title (croatian)Naringenin reducira histopatološke promjene u jetri i bubregu miševa s dijabetesom
Title (english)Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study
AuthorDamir Sirovina
AuthorNada Oršolić
AuthorMarijana Zovko Končić
AuthorGordana Gregorović
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmacognosy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
Istražen je učinak naringenina, flavonoida dostupnoga iz grejpa, naranče i rajčice, na razinu lipidne peroksidacije te patohistološke promjene u jetri i bubregu miševa s dijabetesom prouzročenim aloksanom. Dva dana nakon injekcije aloksana (75 mg kg-1, iv) započeta je terapija etanolnom otopinom naringenina (0.5% v / v). Naringenin je injiciran miševima intraperitonealno u dozi od 50 mg kg-1 tijekom sedam dana. Učinak naringenina na razinu lipidne peroksidacije određen je metodom s tiobarbiturnom kiselinom, a histopatološke promjene jetre i bubrega utvrđene su svjetlosnim mikroskopom. Terapija naringeninom prouzročila je značajno smanjenje ne samo razine lipidne peroksidacije u tkivu jetre i bubrega nego i broja vakuoliziranih stanica jetre te stupnja njihove vakuolizacije. Naznake oporavka tkiva u bubregu navode na zaključak da bi dugotrajna terapija mogla smanjiti oštećenja bubrega prouzročena dijabetesom. Zaštitni učinak naringenina u razvoju dijabetičkih komplikacija u miševa daje nadu da je sličan, pozitivan učinak moguć i u ljudi.
Abstract (english)
The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg-1, i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg-1 per day) for seven days. Naringenin’s impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected wih oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 67, no. 1, pp. 19-24
p-ISSN0004-1254
e-ISSN1848-6312
DOIhttps://doi.org/10.1515/aiht-2016-67-2708
URN:NBNurn:nbn:hr:163:182999
Publication2016
Document URLhttps://hrcak.srce.hr/154583
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-14 15:55:26