prikaz prve stranice dokumenta Kemizam i biološki učinci gliotoksina
  Download
PDF 363.59 KB
Scientific paper - Review paper
Kemizam i biološki učinci gliotoksina
Arhiv za higijenu rada i toksikologiju, 55 (2004), 4; 313-320. urn:nbn:hr:163:963336
Kosalec, Ivan; Pepeljnjak, Stjepan

Institutional repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb

Cite this document

Kosalec, I. & Pepeljnjak, S. (2004). Kemizam i biološki učinci gliotoksina. Arhiv za higijenu rada i toksikologiju, 55. (4), 313-320. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:963336

Kosalec, Ivan and Stjepan Pepeljnjak. "Kemizam i biološki učinci gliotoksina." Arhiv za higijenu rada i toksikologiju, vol. 55, no. 4, 2004, pp. 313-320. https://urn.nsk.hr/urn:nbn:hr:163:963336

Kosalec, Ivan and Stjepan Pepeljnjak. "Kemizam i biološki učinci gliotoksina." Arhiv za higijenu rada i toksikologiju 55, no. 4 (2004): 313-320. https://urn.nsk.hr/urn:nbn:hr:163:963336

Kosalec, I. and Pepeljnjak, S. (2004) 'Kemizam i biološki učinci gliotoksina', Arhiv za higijenu rada i toksikologiju, 55(4), pp. 313-320. Available at: https://urn.nsk.hr/urn:nbn:hr:163:963336 (Accessed 26 November 2024)

Kosalec I, Pepeljnjak S. Kemizam i biološki učinci gliotoksina. Arhiv za higijenu rada i toksikologiju [Internet]. 2004 [cited 2024 November 26];55(4):313-320. Available at: https://urn.nsk.hr/urn:nbn:hr:163:963336

I. Kosalec and S. Pepeljnjak, "Kemizam i biološki učinci gliotoksina", Arhiv za higijenu rada i toksikologiju, vol. 55, no. 4, pp. 313-320, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:963336. [Accessed: 26 November 2024]

Metadata
Title (croatian)Kemizam i biološki učinci gliotoksina
Title (english)Chemistry and Biological Effects of Gliotoxin
AuthorIvan Kosalec
AuthorStjepan Pepeljnjak
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of microbiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (croatian)
Gliotoksin je mikotoksin iz skupine epipolitiodioksopiperazina s biološki aktivnim internim disulfidnim mostom. Gliotoksin ima antibakterijski i virucidan učinak (nekada se rabio kao antibiotik, no zbog toksičnosti je izbačen iz kliničke uporabe). Najviše proučavan učinak gliotoksina je na stanice imunosnog sustava, pa se pokušavaju gliotoksinom ili njegovim analozima obraditi presadci ex situ radi smanjenja učestalosti odbacivanja organa i tvorbe “imunosno tihih” presadaka. Toksičnost gliotoksina dokazana je na nizu staničnih linija (makrofazi, timociti, splenociti, fibroblasti) gdje izaziva apoptozu i nekrozu te inhibiranjem niza enzima (farnezil-transferazu, NF-κB, alkohol-dehidrogenazu). Toksičnost gliotoksina povezana je sa stvaranjem kovalentnih i miješanih disulfidnih veza te oksidativnim učincima. Gliotoksin tvore plijesan Aspergillus fumigatus i gljivica Candida albicans te se pretpostavlja da će tvorba ovog toksina, zbog dokazanih toksičkih učinaka na mjestu mikoze (invazivne aspergiloze i kandidijaze) imati učinak na egzacerbaciju mikoze odnosno pridonijeti invazivnosti gliotoksinogenih gljivica.
Abstract (english)
Gliotoxin is a mycotoxin from the epipolythiodioxypipeazine family with biological active internal disulfide bridge. Gliotoxin has an antibacterial and antiviral activity, but it was discarded from clinical practice due to its toxicity. The most studied effect of gliotoxin is its influence on the cell of the immune system. Today, researches are focused on treating transplantation organs ex situ and making them immunologically silent. Its toxicity has been proven on several cells (macrophages, thymocites, splenocytes, and fibroblasts) causing apoptosis and necrosis and it has acted as inhibitor of several enzymes (farnesyl-transefases, NF-κB, and alcohol-dehydrogenases). Its mechanism of toxicity is connected with the production of mixed disulfide and covalent bonds, and oxidative effects. An important medical mould Aspergillus fumigatus and yeast Candida albicans can secrete gliotoxin in infected tissues and, because of the proven toxic effects of gliotoxin, it is suggested that gliotoxin can exacerbate mycoses (invasive aspergillosis or candidiasis). Gliotoxin can also affect the invasiveness of fungi and their dissemination from the primary site throughout the organism.
Keywords (croatian)
Keywords (english)
Languagecroatian
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleArhiv za higijenu rada i toksikologiju
Numberingvol. 55, no. 4, pp. 313-320
p-ISSN0004-1254
e-ISSN1848-6312
URN:NBNurn:nbn:hr:163:963336
Publication2004
Document URLhttps://hrcak.srce.hr/260
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-05-19 14:25:39