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Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova
Farmaceutski glasnik, 73 (2017), 1; 1-16. urn:nbn:hr:163:464207
Antolić, Andrea; Bojić, Mirza

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Antolić, A. & Bojić, M. (2017). Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova. Farmaceutski glasnik, 73. (1), 1-16. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:464207

Antolić, Andrea and Mirza Bojić. "Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova." Farmaceutski glasnik, vol. 73, no. 1, 2017, pp. 1-16. https://urn.nsk.hr/urn:nbn:hr:163:464207

Antolić, Andrea and Mirza Bojić. "Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova." Farmaceutski glasnik 73, no. 1 (2017): 1-16. https://urn.nsk.hr/urn:nbn:hr:163:464207

Antolić, A. and Bojić, M. (2017) 'Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova', Farmaceutski glasnik, 73(1), pp. 1-16. Available at: https://urn.nsk.hr/urn:nbn:hr:163:464207 (Accessed 26 November 2024)

Antolić A, Bojić M. Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova. Farmaceutski glasnik [Internet]. 2017 [cited 2024 November 26];73(1):1-16. Available at: https://urn.nsk.hr/urn:nbn:hr:163:464207

A. Antolić and M. Bojić, "Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova", Farmaceutski glasnik, vol. 73, no. 1, pp. 1-16, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:464207. [Accessed: 26 November 2024]

Metadata
Title (croatian)Značenje reakcija biotransformacija u pojavi idiosinkratskih reakcija lijekova
AuthorAndrea Antolić
AuthorMirza Bojić
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of medicinal chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Idiosyncratic drug reactions (IDRs) are rare, dose independent adverse drug reactions. Although non-predictable they are not idiopathic and their causes can be rationalized. Drugs susceptible to IDRs usually undergo extensive metabolism. Most common cause of IDRs are reactive metabolites generated through drug biotransformation. In this paper an overview of drugs susceptible to IDRs is given, based on effected organs. IDRs on skin are illustrated with metabolism phenytoin and nevirapine. Hematological IDRs are exemplified with clozapine and felbamate. Hepatotoxicity related to IDRs is explained on valproic acid, troglitazone and ximelagatran. Among strategies on how to reduce occurrence of IDRs include avoidance of specific functional groups (toxicophores) present a viable option.
Keywords (croatian)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleFarmaceutski glasnik
Numberingvol. 73, no. 1, pp. 1-16
p-ISSN0014-8202
URN:NBNurn:nbn:hr:163:464207
Publication2017
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-06-19 10:11:07